AIMC Topic: Gastrointestinal Microbiome

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Microorganisms, Microbial Metabolites and Precision Nutrition: Targeting the Gut-Skin Axis for Immune Microenvironment Remodeling in Atopic Dermatitis.

Clinical reviews in allergy & immunology
Atopic dermatitis (AD), characterized by skin barrier dysfunction and microbiota dysbiosis, is closely linked to immune microenvironment imbalance. Growing evidence highlights the crucial role of microorganisms and their metabolites in immune regulat...

A systematic longitudinal study of microbiome: integrating temporal-spatial dimensions with causal and deep learning models.

BMC genomics
Longitudinal microbiome data provide a unique opportunity to explore dynamic interactions between microbial communities and disease progression. However, these data are often characterized by missing values, sparse signals, and limited interpretabili...

Association between gut microbiota composition and physical functioning in patients with knee osteoarthritis: a machine learning study.

Scientific reports
Gut dysbiosis and systemic inflammation are increasingly recognized in the pathogenesis of knee osteoarthritis (OA). While altered gut microbiota profiles have been reported, the link between specific microbial taxa and physical functioning in OA pat...

The gut-bone axis in ankylosing spondylitis: mechanistic insights and the translational gap.

Clinical and experimental medicine
The gut-bone axis is pivotal in the pathogenesis of ankylosing spondylitis (AS), with gut dysbiosis and mucosal immune activation driving skeletal pathology. However, translating these mechanistic insights into effective therapies remains challenging...

A lightweight single-view contrastive learning hypergraph neural network for food-microbe-disease association prediction.

BMC bioinformatics
BACKGROUND: Identifying potential associations among food, gut microbiota and disease is fundamental for elucidating interaction mechanisms and advancing personalized healthy dietary strategies. While computational methods have been extensively appli...

Artificial intelligence in gut microbiome research: Toward predictive diagnostics for neurodegenerative disorders.

Acta microbiologica et immunologica Hungarica
The human gut microbiota plays a pivotal role in maintaining host immunity, regulating metabolism, and sustaining neurophysiological homeostasis. Increasing evidence implicates gut dysbiosis in the onset and progression of neurodegenerative disorders...

Rebuilding the gut ecosystem: Emerging strategies targeting the microbiota in antibiotic-associated diarrhea.

Acta microbiologica et immunologica Hungarica
Antibiotic-associated diarrhea (AAD) is a prevalent iatrogenic complication of antibiotic therapy, primarily triggered by dysbiosis and loss of intestinal homeostasis. The traditional interventions, such as empirical probiotic use, have shown a modes...

The usefulness of microbiome profiling for geriatric patients with neuropsychiatric conditions: a scoping review.

Translational psychiatry
INTRODUCTION: Neuropsychiatric disorders encompass psychiatric and neurodegenerative diseases. These conditions are particularly challenging to diagnose in the elderly due to their overlapping cognitive, affective, and behavioural symptoms. Recent st...

Gilthead sea bream gut bacteriome as a valuable tool for seafood provenance analysis.

Applied and environmental microbiology
The increasing demand for high-quality seafood underscores the significant challenges posed by rampant seafood fraud. This study aimed to identify regional capture biomarkers by using the gut bacteriome of specimens through state-of-the-art long-rea...

Gut microbiota predictive of the efficacy of consolidation immunotherapy and chemoradiotherapy toxicity in lung cancer.

Med (New York, N.Y.)
BACKGROUND: Gut microbiota (GM) predict responses to immune checkpoint inhibitors (ICIs) in patients with advanced lung cancer. However, its role in patients with locally advanced lung cancer undergoing chemoradiotherapy (CRT) combined with consolida...