AIMC Topic: Gene Expression Profiling
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Unveiling the role of coagulation-related genes in acute myeloid leukemia prognosis and immune microenvironment through machine learning.
European journal of medical research
Aug 11, 2025
BACKGROUND: Acute Myeloid Leukemia (AML) is a highly heterogeneous hematologic malignancy influenced by various factors affecting prognosis. Recently, the role of coagulation-related genes in tumor biology has garnered increasing attention. This stud...
Exploration of autophagy-associated genes and potential molecular mechanisms in type 1 diabetes and osteoporosis.
Scientific reports
Aug 11, 2025
The co-occurrence of osteoporosis (OP) and type 1 diabetes mellitus (T1DM) represents a clinically significant comorbidity pattern, characterized by skeletal fragility and insulin deficiency. While epidemiological links exist, their shared molecular ...
Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy.
Communications biology
Aug 10, 2025
Idiopathic membranous nephropathy (IMN) is the major cause of autoimmune-related nephrotic syndrome. The role immune cells play in the risk and prognosis of IMN remains elusive. We employ multi-omics data and a variety of approaches to evaluate the c...
Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in the influence of short-chain fatty acids on the development of sepsis.
Scientific reports
Aug 9, 2025
Sepsis is a systemic inflammatory response syndrome caused by infection, which has a high morbidity and mortality. Short-chain fatty acids (SCFAs) have been proved to improve the outcome of sepsis by regulating immunity and metabolism, but its specif...
Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson's disease.
Hereditas
Aug 8, 2025
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. The role of protein post-translational modifications (PTMs), especially small ubiquitin-like modifier (SUMO) conjugation (SUMOylation), in PD pathogenesis remains unclear. T...
Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure.
Hereditas
Aug 8, 2025
BACKGROUND: Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response....
Identification and validation of hub genes related to neutrophil extracellular traps-mediated cell damage and immune recruitment during abdominal aortic aneurysm.
Scientific reports
Aug 7, 2025
Previous research has shown that the formation of Neutrophil Extracellular Traps (NETs), mediated by neutrophils, leads to an increase in inflammatory cell response and cellular tissue damage during Abdominal Aortic Aneurysm (AAA). Building on this f...
Network-based approach identifies key genes associated with tumor heterogeneity in HPV positive and negative head and neck cancer patients.
Scientific reports
Aug 7, 2025
Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most prevalent cancer worldwide and is classified as human papillomavirus (HPV) positive or negative. Substantial heterogeneity has been observed in the two groups, posing a significant cli...
Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy.
Scientific reports
Aug 7, 2025
Diabetic nephropathy (DN) is a kidney disease. Mitochondrial and endoplasmic reticulum stress (ERS) significantly contribute to diabetic nephropathy (DN), although the precise mechanisms involved have not yet been fully understood. The objective of t...
Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network.
Scientific reports
Aug 6, 2025
Lung adenocarcinoma (LUAD), the most common non-small cell lung cancer subtype, often presents with subtle early symptoms leading to delayed diagnosis. Ferroptosis, a cell death process associated with iron metabolism dysregulation, has been linked t...
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