Currently, research has found a close correlation between childhood obesity (CO) and elevated levels of polyamines in the bloodstream. Thus, the identification of key genes associated with polyamines metabolism in CO could offer fresh insights for cl...
BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies...
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment...
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between RA and telomeres.
BACKGROUND: Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions. However, despite its potential, gene expression...
BACKGROUND: Epithelial ovarian cancer (EOC) is a deadly and heterogenous disease comprising five major histotypes: clear cell carcinoma (CCC), endometrioid carcinoma (EC), low- and high-grade serous carcinoma (LGSC, HGSC), and mucinous carcinoma (MC)...
Journal of orthopaedic surgery and research
May 16, 2025
BACKGROUND: Thrombus formation is a severe complication in orthopedic surgery, significantly increasing mortality in patients with fractures. Therefore, identifying feature genes to determine thrombus presence in fracture surgeries is critical.
Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM). First, GEP will ...
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with complex molecular underpinnings. Hodgkin lymphoma (HL), another distinct cancer type, shares several biological characteristics with HNSCC, particularly regarding im...
Evidence indicates a connection between periodontitis (PD) and systemic lupus erythematosus (SLE), though the underlying co-morbid mechanisms remain unclear. This study sought to identify the genetic factors and potential therapeutic agents involved ...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.