This study presents the development of new empirical prediction models to evaluate swell pressure and unconfined compression strength of expansive soils (PUCS-ES) using three soft computing methods, namely artificial neural networks (ANNs), adaptive ...
Multi-domain proteins are not only formed through natural evolution but can also be generated by recombinant DNA technology. Because many fusion proteins can enhance the selectivity of cell targeting, these artificially produced molecules, called mul...
Mesenchymal stromal cells (MSCs) are multipotent cells that have great potential for regenerative medicine, tissue repair, and immunotherapy. Unfortunately, the outcomes of MSC-based research and therapies can be highly inconsistent and difficult to ...
Medical & biological engineering & computing
Feb 5, 2021
In the medical field, successful classification of microarray gene expression data is of major importance for cancer diagnosis. However, due to the profusion of genes number, the performance of classifying DNA microarray gene expression data using st...
International journal of molecular sciences
Jan 22, 2021
One of the important questions in aging research is how differences in transcriptomics are associated with the longevity of various species. Unfortunately, at the level of individual genes, the links between expression in different organs and maximum...
Journal of orthopaedic surgery and research
Jan 11, 2021
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a substantial burden for both patients and society. Early diagnosis of RA is essential to prevent disease progression and select an optimal therapeutic strategy. Ho...
Machine learning approaches are becoming increasingly widespread and are now present in most areas of research. Their recent surge can be explained in part due to our ability to generate and store enormous amounts of data with which to train these mo...
Journal of integrative bioinformatics
Dec 29, 2020
Breast cancer is the leading diseases of death in women. It induces by a genetic mutation in breast cancer cells. Genetic testing has become popular to detect the mutation in genes but test cost is relatively expensive for several patients in develop...
BACKGROUND: Schizophrenia (SCZ) is a highly heritable mental disorder with a substantial disease burden. Machine learning (ML) method can be used to identify individuals with SCZ on the basis of blood gene expression data with high accuracy.
BACKGROUND: One possible approach how to economically facilitate gene expression profiling is to use the L1000 platform which measures the expression of ∼1,000 landmark genes and uses a computational method to infer the expression of another ∼10,000 ...