AIMC Topic: Gene Expression

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Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination.

PLoS computational biology May 3, 2021
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or...
Mice, Inbred C57BL Gene Expression B-Lymphocytes Supervised Machine Learning Mice Computational Biology Signal Transduction Basic-Leucine Zipper Transcription Factors Immunoglobulin Class Switching NF-kappa B p50 Subunit STAT6 Transcription Factor Databases, Nucleic Acid Models, Immunological Receptors, Cytokine Recombination, Genetic Neural Networks, Computer Interleukin-4 Immunoglobulin G Computer Simulation Animals Single-Cell Analysis RNA-Seq
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Jaya Ant lion optimization-driven Deep recurrent neural network for cancer classification using gene expression data.

Medical & biological engineering & computing Apr 13, 2021
Cancer is one of the deadly diseases prevailing worldwide and the patients with cancer are rescued only when the cancer is detected at the very early stage. Early detection of cancer is essential as, in the final stage, the chance of survival is limi...
Humans Neural Networks, Computer Algorithms Databases, Factual Neoplasms Gene Expression
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Predictive modeling of swell-strength of expansive soils using artificial intelligence approaches: ANN, ANFIS and GEP.

Journal of environmental management Apr 5, 2021
This study presents the development of new empirical prediction models to evaluate swell pressure and unconfined compression strength of expansive soils (PUCS-ES) using three soft computing methods, namely artificial neural networks (ANNs), adaptive ...
Neural Networks, Computer Artificial Intelligence Soil Gene Expression
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Characterizing the function of domain linkers in regulating the dynamics of multi-domain fusion proteins by microsecond molecular dynamics simulations and artificial intelligence.

Proteins Mar 27, 2021
Multi-domain proteins are not only formed through natural evolution but can also be generated by recombinant DNA technology. Because many fusion proteins can enhance the selectivity of cell targeting, these artificially produced molecules, called mul...
Protein Domains Amino Acids Benchmarking Molecular Dynamics Simulation Artificial Intelligence Computational Biology Gene Expression Mutagenesis, Insertional Recombinant Fusion Proteins Protein Engineering Pliability Humans
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Investigating heterogeneities of live mesenchymal stromal cells using AI-based label-free imaging.

Scientific reports Mar 24, 2021
Mesenchymal stromal cells (MSCs) are multipotent cells that have great potential for regenerative medicine, tissue repair, and immunotherapy. Unfortunately, the outcomes of MSC-based research and therapies can be highly inconsistent and difficult to ...
Computational Biology Gene Expression Flow Cytometry Mesenchymal Stem Cells Molecular Imaging Fluorescent Antibody Technique Biomarkers Gene Expression Profiling Image Processing, Computer-Assisted Staining and Labeling Artificial Intelligence
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Optimizing ANFIS using simulated annealing algorithm for classification of microarray gene expression cancer data.

Medical & biological engineering & computing Feb 5, 2021
In the medical field, successful classification of microarray gene expression data is of major importance for cancer diagnosis. However, due to the profusion of genes number, the performance of classifying DNA microarray gene expression data using st...
Bayes Theorem Gene Expression Humans Neural Networks, Computer Artificial Intelligence Algorithms Male Neoplasms Fuzzy Logic
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Machine Learning Analysis of Longevity-Associated Gene Expression Landscapes in Mammals.

International journal of molecular sciences Jan 22, 2021
One of the important questions in aging research is how differences in transcriptomics are associated with the longevity of various species. Unfortunately, at the level of individual genes, the links between expression in different organs and maximum...
Models, Genetic Liver Regression Analysis Bayes Theorem Humans Tissue Distribution Transcriptome Brain Machine Learning Longevity RNA-Seq Animals Algorithms Gene Expression Aging Computational Biology Mammals Gene Expression Profiling Linear Models
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A 9 mRNAs-based diagnostic signature for rheumatoid arthritis by integrating bioinformatic analysis and machine-learning.

Journal of orthopaedic surgery and research Jan 11, 2021
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a substantial burden for both patients and society. Early diagnosis of RA is essential to prevent disease progression and select an optimal therapeutic strategy. Ho...
RNA, Messenger Logistic Models Gene Expression Actins Microfilament Proteins Cofilin 1 Humans Profilins Male Machine Learning Forecasting Gene Expression Profiling Biomarkers Arthritis, Rheumatoid Female Computational Biology
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A deep learning approach for staging embryonic tissue isolates with small data.

PloS one Jan 8, 2021
Machine learning approaches are becoming increasingly widespread and are now present in most areas of research. Their recent surge can be explained in part due to our ability to generate and store enormous amounts of data with which to train these mo...
Tail Microscopy, Confocal Gene Expression Zebrafish Embryo, Nonmammalian Animals Deep Learning Image Processing, Computer-Assisted
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A novel gene expression test method of minimizing breast cancer risk in reduced cost and time by improving SVM-RFE gene selection method combined with LASSO.

Journal of integrative bioinformatics Dec 29, 2020
Breast cancer is the leading diseases of death in women. It induces by a genetic mutation in breast cancer cells. Genetic testing has become popular to detect the mutation in genes but test cost is relatively expensive for several patients in develop...
Breast Neoplasms Humans Gene Expression Profiling Machine Learning Support Vector Machine Female Gene Expression
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