Migraine has an assumed polygenic basis, but the genetic risk variants identified in genome-wide association studies only explain a proportion of the heritability. We aimed to develop machine learning models, capturing non-additive and interactive ef...
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Dec 25, 2025
Warfarin, a classic oral anticoagulant, is characterized by a narrow therapeutic window and considerable interindividual variability in dosing requirements. This makes precise dose adjustment challenging in clinical practice and increases the risk of...
UNLABELLED: Dysregulation of the tumor suppressor gene adenomatous polyposis coli (APC) is a canonical step in colorectal cancer development by promoting activation of the WNT/β-catenin pathway. Curiously, most colorectal tumors carry biallelic mutat...
OBJECTIVES: Methicillin-resistant (MRSA) is a major public health concern because of its genotypic diversity and association with severe infections, particularly those caused by strains carrying Panton-Valentine leukocidin (PVL). This study aimed to...
p53 immunohistochemistry (IHC) is widely used as a rapid surrogate for detecting mutations, with mutations being a key biomarker for poor outcomes in lymphomas. We developed two algorithms using digital quantification tools to assess p53 expression...
The journal of applied laboratory medicine
Sep 3, 2025
BACKGROUND: The D-elution (DEL) phenotype is serologically mislabeled as Rh-negative because of the very low amount of D antigen on red blood cells. The adsorption-elution test and genotyping are recommended tests for confirmation. However, turnaroun...
Rice (Oryza sativa L.) is a staple food for more than half of the global population. Preharvest sprouting (PHS), which reduces yield and grain quality, presents a major challenge for rice production. The development of PHS-resistant varieties is a ma...
Studies in health technology and informatics
Aug 7, 2025
Interpreting and subtyping type 2 diabetes (T2D) is challenging yet essential for achieving fine-grained pathophysiological insights and precise clinical stratification. Previous studies have primarily relied on a small number of pre-selected risk fa...
Reduction in the costs of DNA sequencing and genotyping allows for the increased availability of databases which can be useful for analyzing the relationship between the human genetic code and visible characteristics, diseases, and behaviors, among o...
UNLABELLED: Cancer drug resistance is multifactorial, driven by heritable (epi)genetic changes but also by phenotypic plasticity. In this study, we dissected the drivers of resistance by perturbing organoids derived from patients with colorectal canc...
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