AIMC Topic: Hepatitis C, Chronic

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Comparison of Machine Learning Approaches for Prediction of Advanced Liver Fibrosis in Chronic Hepatitis C Patients.

IEEE/ACM transactions on computational biology and bioinformatics Apr 4, 2017
BACKGROUND/AIM: Using machine learning approaches as non-invasive methods have been used recently as an alternative method in staging chronic liver diseases for avoiding the drawbacks of biopsy. This study aims to evaluate different machine learning ...
Disease Progression Diagnosis, Computer-Assisted Adolescent ROC Curve Liver Cirrhosis Female Young Adult Adult Male Middle Aged Models, Statistical Hepatitis C, Chronic Machine Learning Algorithms Biomarkers Humans
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A methodology for automated CPA extraction using liver biopsy image analysis and machine learning techniques.

Computer methods and programs in biomedicine Nov 29, 2016
BACKGROUND AND OBJECTIVE: Collagen proportional area (CPA) extraction in liver biopsy images provides the degree of fibrosis expansion in liver tissue, which is the most characteristic histological alteration in hepatitis C virus (HCV). Assessment of...
Humans Machine Learning Liver Biopsy Hepatitis C, Chronic Collagen Automation
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Sulfonamides Hepacivirus Administration, Oral Proline Ritonavir Drug Administration Schedule Anilides Carbamates Drug Therapy, Combination Hepatitis C, Chronic Valine Liver Cirrhosis Treatment Outcome Follow-Up Studies Cyclopropanes Egypt Male Middle Aged Adolescent Antiviral Agents Genotype Lactams, Macrocyclic Macrocyclic Compounds Ribavirin Sustained Virologic Response Humans Female Aged Aged, 80 and over Young Adult Adult
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Sustained Virologic Response Anilides Carbamates Lactams, Macrocyclic Macrocyclic Compounds Ribavirin Ritonavir Drug Therapy, Combination Hepatitis C, Chronic Valine Drug Administration Schedule Male Middle Aged Adolescent Antiviral Agents Genotype Sulfonamides Hepacivirus Proline Treatment Outcome Follow-Up Studies Cyclopropanes Female Aged Aged, 80 and over Young Adult Adult Humans
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'I'm over the moon!': patient-perceived outcomes of hepatitis C treatment.

Australian journal of primary health Aug 1, 2020
Understanding patient-perceived outcomes is crucial for assessing the effectiveness and acceptability of hepatitis C virus (HCV) treatment. This study aimed to explore patient-perceived outcomes of receiving direct-acting antivirals (DAAs). This stud...
Antiviral Agents Treatment Outcome Outcome Assessment, Health Care Hepatitis C, Chronic Queensland Attitude to Health Humans Neural Networks, Computer Interviews as Topic
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[A real-world study of paritaprevir/ritonavir-ombitasvir combined with dasabuvir in the treatment of genotype 1b chronic hepatitis C].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dec 20, 2018
To recognize the efficacy and safety of paritaprevir/ritonavir-ombitasvir combined with dasabuvir (OBV/PTV/RTV+DSV) in the treatment of genotype 1b chronic hepatitis C. Patients with genotype 1b chronic hepatitis C who were admitted to the People's...
Drug Therapy, Combination Hepatitis C, Chronic Valine Anilides Carbamates Cyclopropanes Sulfonamides Hepacivirus Proline Ritonavir Lactams, Macrocyclic Macrocyclic Compounds Ribavirin 2-Naphthylamine Uracil Humans Male Middle Aged China Antiviral Agents Genotype Treatment Outcome
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WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS.

Arquivos de gastroenterologia Jan 1, 2018
BACKGROUND: The infection for the hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality through its evolution to liver cirrhosis, end-stage liver complications and hepatocellular carcinoma. Currently, the new drugs for t...
Hepacivirus Waiting Lists Hepatitis C, Chronic Middle Aged Incidence Liver Neoplasms Antiviral Agents Liver Cirrhosis Humans Prospective Studies Female Risk Factors Male
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Association of ATP-Binding Cassette Transporter (ABC) Gene Polymorphisms with Viral Load in Patients with Genotype 1 Hepatitis C Virus Infection.

Clinical laboratory Sep 1, 2016
BACKGROUND: ATP-binding cassette transporters (ABC) gene polymorphisms are associated with various biological functions, including hepatitis C virus (HCV) infection. This study aims to explore the impact of ABC transporters polymorphisms on HCV viral...
Lipoproteins Interleukins Neoplasm Proteins ATP Binding Cassette Transporter, Subfamily B, Member 1 Hepacivirus Male Middle Aged Viral Load Polymorphism, Single Nucleotide Genotype ATP Binding Cassette Transporter, Subfamily B, Member 11 ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP Binding Cassette Transporter, Subfamily G, Member 5 Hepatitis C, Chronic Gene Frequency ATP-Binding Cassette Transporters ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily B Humans Female
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[Maintenance therapy for chronic hepatitis C].

Gastroenterologie clinique et biologique Jan 1, 2007
Therapy of chronic hepatitis C presently achieves 60% of sustained virological response, with clear on improvement of liver histology. Failure to eradicate HCV infection does not mean that the patient is non-responsive to therapy and indeed most pati...
Humans Disease Progression Antiviral Agents Drug Therapy, Combination Hepatitis C, Chronic
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[Retreatment strategies for the patients with HCV infection].

Przeglad epidemiologiczny Jan 1, 2005
Despite recent advances in the treatment of chronic hepatitis C, especially introduction of combined therapy with pegylated interferons with ribavirin, significant number of patients fails to achieve sustained virologic response. Such patients may be...
Quality-Adjusted Life Years Drug Therapy, Combination Hepatitis C, Chronic Drug Administration Schedule Ribavirin Recurrence Retreatment Treatment Outcome Randomized Controlled Trials as Topic Interferon-alpha Polyethylene Glycols Interferon alpha-2 Humans Antiviral Agents Recombinant Proteins
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