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Histocytochemistry

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Segmentation of histological images and fibrosis identification with a convolutional neural network.

Computers in biology and medicine
Segmentation of histological images is one of the most crucial tasks for many biomedical analyses involving quantification of certain tissue types, such as fibrosis via Masson's trichrome staining. However, challenges are posed by the high variabilit...

Unsupervised Transfer Learning via Multi-Scale Convolutional Sparse Coding for Biomedical Applications.

IEEE transactions on pattern analysis and machine intelligence
The capabilities of (I) learning transferable knowledge across domains; and (II) fine-tuning the pre-learned base knowledge towards tasks with considerably smaller data scale are extremely important. Many of the existing transfer learning techniques ...

Adversarial Stain Transfer for Histopathology Image Analysis.

IEEE transactions on medical imaging
It is generally recognized that color information is central to the automatic and visual analysis of histopathology tissue slides. In practice, pathologists rely on color, which reflects the presence of specific tissue components, to establish a diag...

Feature-Based Representation Improves Color Decomposition and Nuclear Detection Using a Convolutional Neural Network.

IEEE transactions on bio-medical engineering
Detection of nuclei is an important step in phenotypic profiling of 1) histology sections imaged in bright field; and 2) colony formation of the 3-D cell culture models that are imaged using confocal microscopy. It is shown that feature-based represe...

The Spontaneous Control of HIV Replication is Characterized by Decreased Pathological Changes in the Gut-associated Lymphoid Tissue.

Current HIV research
BACKGROUND: HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, severa...

Gastric Pathology Image Classification Using Stepwise Fine-Tuning for Deep Neural Networks.

Journal of healthcare engineering
Deep learning using convolutional neural networks (CNNs) is a distinguished tool for many image classification tasks. Due to its outstanding robustness and generalization, it is also expected to play a key role to facilitate advanced computer-aided d...

Gland Instance Segmentation Using Deep Multichannel Neural Networks.

IEEE transactions on bio-medical engineering
OBJECTIVE: A new image instance segmentation method is proposed to segment individual glands (instances) in colon histology images. This process is challenging since the glands not only need to be segmented from a complex background, they must also b...

Constrained Deep Weak Supervision for Histopathology Image Segmentation.

IEEE transactions on medical imaging
In this paper, we develop a new weakly supervised learning algorithm to learn to segment cancerous regions in histopathology images. This paper is under a multiple instance learning (MIL) framework with a new formulation, deep weak supervision (DWS);...

Epithelium-Stroma Classification via Convolutional Neural Networks and Unsupervised Domain Adaptation in Histopathological Images.

IEEE journal of biomedical and health informatics
Epithelium-stroma classification is a necessary preprocessing step in histopathological image analysis. Current deep learning based recognition methods for histology data require collection of large volumes of labeled data in order to train a new neu...

Two-phase deep convolutional neural network for reducing class skewness in histopathological images based breast cancer detection.

Computers in biology and medicine
Different types of breast cancer are affecting lives of women across the world. Common types include Ductal carcinoma in situ (DCIS), Invasive ductal carcinoma (IDC), Tubular carcinoma, Medullary carcinoma, and Invasive lobular carcinoma (ILC). While...