AIMC Topic: Humans

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Deep learning applications for quantitative and qualitative PET in PET/MR: technical and clinical unmet needs.

Magma (New York, N.Y.)
We aim to provide an overview of technical and clinical unmet needs in deep learning (DL) applications for quantitative and qualitative PET in PET/MR, with a focus on attenuation correction, image enhancement, motion correction, kinetic modeling, and...

Perspectives on the use of machine learning for ADME prediction at AstraZeneca.

Xenobiotica; the fate of foreign compounds in biological systems
A drug's pharmacokinetic (PK) profile will determine its dose and the frequency of administration as well as the likelihood of observing any adverse drug reactions.It is important to understand these PK properties as early as possible in the drug dis...

Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science.

Xenobiotica; the fate of foreign compounds in biological systems
Artificial Intelligence (AI) is poised or has already begun to influence absorption, distribution, metabolism and excretion (ADME) science. It is not in the area expected - that of superior modelling of ADME data to increase its predictive power. It ...

Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning.

Xenobiotica; the fate of foreign compounds in biological systems
Unexpected metabolism could lead to the failure of many late-stage drug candidates or even the withdrawal of approved drugs. Thus, it is critical to predict and study the dominant routes of metabolism in the early stages of research.We describe the d...

Leveraging 3D convolutional neural network and 3D visible-near-infrared multimodal imaging for enhanced contactless oximetry.

Journal of biomedical optics
SIGNIFICANCE: Monitoring oxygen saturation ( ) is important in healthcare, especially for diagnosing and managing pulmonary diseases. Non-contact approaches broaden the potential applications of measurement by better hygiene, comfort, and capabilit...

is a novel marker for bladder cancer prognosis: evidence based on experimental studies, machine learning and single-cell sequencing.

Frontiers in immunology
BACKGROUND: Bladder cancer, a highly fatal disease, poses a significant threat to patients. Positioned at 19q13.2-13.3, LIG1, one of the four DNA ligases in mammalian cells, is frequently deleted in tumour cells of diverse origins. Despite this, the ...

Artificial Intelligence in Chronic Obstructive Pulmonary Disease: Research Status, Trends, and Future Directions --A Bibliometric Analysis from 2009 to 2023.

International journal of chronic obstructive pulmonary disease
OBJECTIVE: A bibliometric analysis was conducted using VOSviewer and CiteSpace to examine studies published between 2009 and 2023 on the utilization of artificial intelligence (AI) in chronic obstructive pulmonary disease (COPD).

Artificial intelligence-based pulmonary embolism classification: Development and validation using real-world data.

PloS one
This paper presents an artificial intelligence-based classification model for the detection of pulmonary embolism in computed tomography angiography. The proposed model, developed from public data and validated on a large dataset from a tertiary hosp...

Machine learning-causal inference based on multi-omics data reveals the association of altered gut bacteria and bile acid metabolism with neonatal jaundice.

Gut microbes
Early identification of neonatal jaundice (NJ) appears to be essential to avoid bilirubin encephalopathy and neurological sequelae. The interaction between gut microbiota and metabolites plays an important role in early life. It is unclear whether th...

Utilizing natural language processing to analyze student narrative reflections for medical curriculum improvement.

Medical teacher
MOTIVATION: Medical curricula improvement is an ongoing process to keep material relevant and improve the student's learning experience to better prepare them for patient care. Many programs utilize end-of-year evaluations, but these frequently have ...