AIMC Topic: Humans

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A magnetic coupled organic SERS platform integrating acetonitrile-driven microextraction and hotspot enrichment: A new strategy for highly sensitive and precise detection of drug molecules in complex matrices.

Biosensors & bioelectronics
The sensitive detection of drug molecules in complex biological samples presents significant challenges, including weak signal intensity, strong matrix interference, and inefficient access of molecules to SERS hotspots. To address these issues, this ...

Organoids as predictive platforms: advancing disease modeling, therapeutic innovation, and drug delivery systems.

Journal of controlled release : official journal of the Controlled Release Society
As three-dimensional (3D), physiologically relevant models, organoids are rapidly becoming revolutionary platforms in biomedical research. With their ability to recapitulate tissue architecture, disease heterogeneity, and patient-specific therapeutic...

Metagenomic research on the structural difference of plaque microbiome from different caries stages and the construction of a caries diagnostic model.

mSystems
Development of dental caries is a dynamic process; yet, there is limited knowledge on microbial differences at various stages of caries at higher resolution. To investigate the shifting microbiome profiles across different caries stages, 30 children ...

Diffusion MRI of the prenatal fetal brain: a methodological scoping review.

NeuroImage
BACKGROUND: Fetal diffusion-weighted Magnetic Resonance Imaging (dMRI) represents a promising modality for the assessment of white matter fiber organization, microstructure and development during pregnancy. Over the past two decades, research using t...

Distinct prefrontal lateralization in placebo and reappraisal mechanisms: An ALE meta-analysis.

NeuroImage
Cognitive reappraisal is an emotional regulation strategy by which the individual changes the perspective on a situation to alter its emotional impact. Similar reinterpretation mechanisms have been associated with the placebo effect in which beliefs ...

Plasma Proteomic High-Performance Biomarkers for Early Diagnosis of Colorectal Cancer.

Journal of proteome research
Colorectal cancer (CRC) is a major global health challenge due to its high incidence, mortality, and low rate of early detection. Early diagnosis, targeting precancerous lesions (advanced adenomas) and early stage CRC (Tis and T1), is critical for im...

Leveraging Deep Learning to Address Diagnostic Challenges with Insufficient Image Data.

ACS sensors
In recent AI-driven disease diagnosis, the success of models has depended mainly on extensive data sets and advanced algorithms. However, creating traditional data sets for rare or emerging diseases presents significant challenges. To address this is...

Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease.

Science advances
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson's disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in...

Printed sensing human-machine interface with individualized adaptive machine learning.

Science advances
Developing intelligent robots with integrated sensing capabilities is critical for advanced manufacturing, medical robots, and embodied intelligence. Existing robotic sensing technologies are limited to recording of acceleration, driving torque, pres...