Journal of controlled release : official journal of the Controlled Release Society
Aug 18, 2025
Nano-sized drug delivery systems have emerged as a more effective, versatile means for improving cancer treatment. However, the complexity of drug delivery to cancer involves intricate interactions between physiological and physicochemical processes ...
Journal of chemical information and modeling
Aug 18, 2025
Antimicrobial peptides (AMPs) have emerged as vital candidates in the fight against antibiotic resistance. The traditional processes for AMP design and discovery are often time-consuming and inefficient. Here, we propose the AMPGP model, which employ...
Journal of chemical information and modeling
Aug 18, 2025
Achieving structural novelty in drug discovery remains a critical challenge. Artificial intelligence (AI) has demonstrated remarkable potential in deciphering the complex relationships between molecular structures and activities from vast amounts of ...
OBJECTIVE: To evaluate the transferability of BERT (Bidirectional Encoder Representations from Transformers) to patient safety, we use it to classify incident reports characterised by limited data and encompassing multiple imbalanced classes.
Rheumatoid arthritis (RA) is a systemic autoimmune disease shaped by complex interactions between genetics and environmental factors, among which gut microbiota has emerged as a critical modulator. Recent advances have implicated gut microbiota dysbi...
Journal of controlled release : official journal of the Controlled Release Society
Aug 16, 2025
Amorphous solid dispersions (ASDs) have emerged as a pivotal strategy in enhancing the dissolution profiles of poorly water-soluble drugs. Although the apparent dissolution rate (both molecular and colloidal drugs) within ASDs has been determined in ...
BACKGROUND: This study aims to apply a semi-supervised machine learning approach for classifying major depressive disorder (MDD) patients into more homogeneous cognitive subtypes based on multidimensional cognitive profiles, and to perform multimodal...
The American journal of sports medicine
Aug 15, 2025
BACKGROUND: Treatment decisions in patients with anterior cruciate ligament (ACL) injuries are influenced by multiple factors, such as the desire to return to sports or symptomatic instability. Identifying the differential treatment effect of ACL rec...
The American journal of sports medicine
Aug 15, 2025
BACKGROUND: Surgeons treating skeletally immature patients use skeletal age to determine appropriate surgical strategies. Traditional bone age estimation methods utilizing hand radiographs are time-consuming.
There is an urgent need for rapid, affordable diagnostics for Alzheimer's disease (AD), particularly those that can detect phosphorylated Tau 181 (p-tau181)─a key biomarker─directly in plasma. We present a scalable, label-free electrochemical biosens...
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