AIMC Topic: Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Extracting Healthcare Quality Information from Unstructured Data.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Healthcare quality research is a fundamental task that involves assessing treatment patterns and measuring the associated patient outcomes to identify potential areas for improving healthcare. While both qualitative and quantitative approaches are us...

Automate Creating, Customizing, and Optimizing Comorbidity Indices Using a Data-Driven AI/ML Approach.

Studies in health technology and informatics
Due to individual differences in severity of illness, clinical studies typically use a comorbidity index to adjust outcomes. With the increasing use of electronic health records (EHRs) to assess the quality of care, a key question arises: how to adju...

A Transformer-Based Framework for Counterfactual Estimation of Antihypertensive Treatment Effect on COVID-19 Infection Risk - A Proof-of-Concept Study.

American journal of hypertension
BACKGROUND: Transformer-based neural networks excel in modelling high-dimensional, time-series data with complex dependencies. This proof-of-concept study applies a transformer-X-learner framework to estimate treatment effects using real-world data, ...

Big Data Cohort Extraction for Personalized Statin Treatment and Machine Learning.

Methods in molecular biology (Clifton, N.J.)
The creation of big clinical data cohorts for machine learning and data analysis require a number of steps from the beginning to successful completion. Similar to data set preprocessing in other fields, there is an initial need to complete data quali...

Effect of simvastatin on the SIRT2/NF-κB pathway in rats with acute pulmonary embolism.

Pharmaceutical biology
CONTEXT: Statins have been widely used in acute pulmonary embolism (APE), while simvastatin has been well-established for the prevention of pulmonary hypertension, which was supposed to be an attractive recommendation for APE treatment.

Machine Learning Outperforms ACC / AHA CVD Risk Calculator in MESA.

Journal of the American Heart Association
Background Studies have demonstrated that the current US guidelines based on American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort Equations Risk Calculator may underestimate risk of atherosclerotic cardiovascular disease ...

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures.

Acta pharmaceutica (Zagreb, Croatia)
Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate deriva...