AIMC Topic: Immunosuppressive Agents

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Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online.

Therapeutic drug monitoring Jun 1, 2018
BACKGROUND: Immunosuppressant Bayesian dose adjustment (ISBA) is an online expert system, routinely used by approximately 140 transplantation centers in the world for the dose adjustment of immunosuppressive drugs in transplant patients. This system ...
Humans Kidney Transplantation Retrospective Studies Female Area Under Curve Adult Drug Monitoring Male Internet Immunosuppressive Agents Tacrolimus Expert Systems
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Predicting Hospitalization and Outpatient Corticosteroid Use in Inflammatory Bowel Disease Patients Using Machine Learning.

Inflammatory bowel diseases Dec 19, 2017
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic disease characterized by unpredictable episodes of flares and periods of remission. Tools that accurately predict disease course would substantially aid therapeutic decision-making. This study...
Humans Machine Learning Inflammatory Bowel Diseases Retrospective Studies Female Risk Factors Hospitalization Male Middle Aged Outpatients Immunosuppressive Agents Area Under Curve Adrenal Cortex Hormones
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Course of hepatitis E infection in a patient with rheumatoid arthritis and autoimmune hepatitis: A case report.

Medicine Dec 1, 2017
RATIONALE: A 62-year-old male patient was admitted to our clinic in February 2016 with persistently elevated liver enzymes.
Hepatitis, Autoimmune Prednisolone Liver Humans Immunosuppressive Agents Male Liver Function Tests Middle Aged Hepatitis E Arthritis, Rheumatoid
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Serum 25-hydroxyvitamin D levels in patients with Granulomatosis with Polyangiitis: association with respiratory infection.

Clinics (Sao Paulo, Brazil) Dec 1, 2017
OBJECTIVES: To determine the possible association of serum 25-hydroxyvitamin D (25OHD) levels with disease activity and respiratory infection in granulomatosis with polyangiitis patients during two different periods: winter/spring and summer/autumn.
Respiratory Tract Infections Granulomatosis with Polyangiitis Prednisone Rituximab Middle Aged Vitamin D Biomarkers Immunosuppressive Agents Female Seasons Adult Male Humans
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Predictable response: Finding optimal drugs and doses using artificial intelligence.

Nature medicine Nov 7, 2017
Graft Rejection Humans Artificial Intelligence Dose-Response Relationship, Drug Immunosuppressive Agents
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Machine Learning Algorithms for Objective Remission and Clinical Outcomes with Thiopurines.

Journal of Crohn's & colitis Jul 1, 2017
BACKGROUND AND AIMS: Big data analytics leverage patterns in data to harvest valuable information, but are rarely implemented in clinical care. Optimising thiopurine therapy for inflammatory bowel disease [IBD] has proved difficult. Current methods u...
Humans Machine Learning Algorithms Inflammatory Bowel Diseases Retrospective Studies ROC Curve Treatment Outcome Immunosuppressive Agents Area Under Curve Remission Induction Drug Prescriptions Male Azathioprine Middle Aged Mercaptopurine Adolescent Female Medication Adherence Hospitalization Young Adult Adult
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Prevalence of cytomegalovirus disease in kidney transplant patients in an intensive care unit.

Revista Brasileira de terapia intensiva Jan 1, 2017
OBJECTIVES: To define the frequency of cytomegalovirus disease among kidney transplant patients in an intensive care unit in which this complication was suspected and to identify predisposing factors and their possible impact on clinical outcome.
Time Factors Humans Cytomegalovirus Infections Logistic Models Kidney Transplantation Polymerase Chain Reaction Retrospective Studies Immunosuppressive Agents Adult Antilymphocyte Serum Intensive Care Units Cytomegalovirus Male Female Middle Aged Aged Prevalence
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Rapamycin inhibits transforming growth factor beta 1 induced myofibroblast differentiation via the phosphorylated-phosphatidylinositol 3-kinase mammalian target of rapamycin signal pathways in nasal polyp-derived fibroblasts.

American journal of rhinology & allergy Nov 1, 2016
PURPOSE: Rapamycin has antiproliferative and antifibrogenic effects in vitro and in vivo. The purpose of this study was to evaluate the effects of rapamycin on transforming growth factor (TGF) beta 1 induced myofibroblast differentiation (alpha smoot...
Extracellular Matrix Actins Phosphatidylinositol 3-Kinase Sirolimus Fibroblasts Immunosuppressive Agents Myofibroblasts Humans Nasal Polyps Cells, Cultured TOR Serine-Threonine Kinases Signal Transduction RNA, Small Interfering Collagen Cell Differentiation Transforming Growth Factor beta
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Minimally invasive kidney transplantation: perioperative considerations and key 6-month outcomes.

Transplantation Feb 1, 2015
BACKGROUND: Minimally invasive approaches to kidney transplantation (KT) have been described recently. However, information concerning perioperative management in these patients is lacking. Accordingly, in the current study, we describe our periopera...
Robotics Kidney Failure, Chronic Fluid Therapy Laparoscopy India Graft Survival Treatment Outcome Immunosuppressive Agents Tertiary Care Centers Surgery, Computer-Assisted Hypothermia, Induced Warm Ischemia Aged Young Adult Adult Male Middle Aged Postoperative Complications Adolescent Time Factors Humans Kidney Transplantation Female Risk Factors
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