AIMC Topic: Intravitreal Injections

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Force classification during robotic interventions through simulation-trained neural networks.

International journal of computer assisted radiology and surgery Aug 16, 2019
PURPOSE: Intravitreal injection is among the most frequent treatment strategies for chronic ophthalmic diseases. The last decade has seen a serious increase in the number of intravitreal injections, and with it, adverse effects and drawbacks. To tack...
Animals Swine Image Processing, Computer-Assisted Models, Theoretical Tomography, Optical Coherence Humans Bayes Theorem Neural Networks, Computer Machine Learning Computer Simulation Reproducibility of Results Robotic Surgical Procedures Intravitreal Injections Diagnostic Techniques, Ophthalmological Mechanical Phenomena Sclera
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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Apr 11, 2018
OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR...
Random Allocation Retinal Diseases Animals, Newborn Hyperoxia In Situ Nick-End Labeling Apoptosis Intravitreal Injections Animals Dose-Response Relationship, Drug Microscopy, Electron Mice Fibrinolytic Agents Cell Proliferation Oxygen Disease Models, Animal Retina Mice, Inbred BALB C Xanthophylls
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Predicting Visual Acuity by Using Machine Learning in Patients Treated for Neovascular Age-Related Macular Degeneration.

Ophthalmology Feb 14, 2018
PURPOSE: To predict, by using machine learning, visual acuity (VA) at 3 and 12 months in patients with neovascular age-related macular degeneration (AMD) after initial upload of 3 anti-vascular endothelial growth factor (VEGF) injections.
Machine Learning Algorithms Databases, Factual Female Reproducibility of Results Aged Aged, 80 and over Male Middle Aged Disease Progression Angiogenesis Inhibitors Choroidal Neovascularization Humans Follow-Up Studies Visual Acuity Vascular Endothelial Growth Factor A Intravitreal Injections Wet Macular Degeneration
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Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Dec 30, 2017
BACKGROUND: To investigate the levels of VEGF in the systemic circulation of patients with type 1 ROP who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB).
Biomarkers Vascular Endothelial Growth Factors Prognosis Intravitreal Injections Female Humans Recombinant Fusion Proteins Enzyme-Linked Immunosorbent Assay Infant, Newborn Prospective Studies Receptors, Vascular Endothelial Growth Factor Male Angiogenesis Inhibitors Retinopathy of Prematurity Time Factors Treatment Outcome Follow-Up Studies Dose-Response Relationship, Drug
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Machine Learning to Analyze the Prognostic Value of Current Imaging Biomarkers in Neovascular Age-Related Macular Degeneration.

Ophthalmology. Retina May 31, 2017
PURPOSE: To evaluate the potential of machine learning to predict best-corrected visual acuity (BCVA) outcomes from structural and functional assessments during the initiation phase in patients receiving standardized ranibizumab therapy for neovascul...
Tomography, Optical Coherence Fundus Oculi Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Ranibizumab Reproducibility of Results Macula Lutea Humans Retinal Pigment Epithelium Angiogenesis Inhibitors Machine Learning Wet Macular Degeneration Treatment Outcome Prospective Studies Follow-Up Studies Prognosis Visual Acuity
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Fluid fluctuations assessed with artificial intelligence during the maintenance phase impact anti-vascular endothelial growth factor visual outcomes in a multicentre, routine clinical care national age-related macular degeneration database.

The British journal of ophthalmology Sep 23, 2025
AIM: To evaluate the impact of fluid volume fluctuations quantified with artificial intelligence in optical coherence tomography scans during the maintenance phase and visual outcomes at 12 and 24 months in a real-world, multicentre, national cohort ...
Humans Artificial Intelligence Databases, Factual Female Aged Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Ranibizumab Aged, 80 and over Wet Macular Degeneration Male Subretinal Fluid Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Tomography, Optical Coherence
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 1, 2025
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
Humans Male Middle Aged Deep Learning Angiogenesis Inhibitors Treatment Outcome Follow-Up Studies Biomarkers Retrospective Studies Female Aged Aged, 80 and over Fluorescein Angiography Recombinant Fusion Proteins Wet Macular Degeneration Receptors, Vascular Endothelial Growth Factor Dose-Response Relationship, Drug Visual Acuity Tomography, Optical Coherence Vascular Endothelial Growth Factor A Intravitreal Injections
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GENERATIVE DEEP LEARNING APPROACH TO PREDICT POSTTREATMENT OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AGE-RELATED MACULAR DEGENERATION AFTER 12 MONTHS.

Retina (Philadelphia, Pa.) Jun 1, 2025
PURPOSE: Predicting long-term anatomical responses in neovascular age-related macular degeneration patients is critical for patient-specific management. This study validates a generative deep learning model to predict 12-month posttreatment optical c...
Wet Macular Degeneration Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Macula Lutea Ranibizumab Female Aged Aged, 80 and over Humans Time Factors Male Retrospective Studies Deep Learning Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Tomography, Optical Coherence Fundus Oculi
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Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method.

Translational vision science & technology Sep 3, 2024
PURPOSE: We evaluated the features predicting visual acuity (VA) after one year in neovascular age-related macular degeneration (nAMD) patients.
Indocyanine Green Intravitreal Injections Fluorescein Angiography Ranibizumab Wet Macular Degeneration Middle Aged ROC Curve Angiogenesis Inhibitors Visual Acuity Tomography, Optical Coherence Humans Machine Learning Retrospective Studies Female Aged Aged, 80 and over Male
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IMPACT OF RESIDUAL SUBRETINAL FLUID VOLUMES ON TREATMENT OUTCOMES IN A SUBRETINAL FLUID-TOLERANT TREAT-AND-EXTEND REGIMEN.

Retina (Philadelphia, Pa.) Nov 1, 2021
PURPOSE: To investigate associations between residual subretinal fluid (rSRF) volumes, quantified using artificial intelligence and treatment outcomes in a subretinal fluid (SRF)-tolerant treat-and-extend (T&E) regimen in neovascular age-related macu...
Ranibizumab Wet Macular Degeneration Subretinal Fluid Drug Tolerance Visual Acuity Tomography, Optical Coherence Fundus Oculi Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Artificial Intelligence Prospective Studies Angiogenesis Inhibitors Treatment Outcome Follow-Up Studies Humans
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