AIMC Topic: Intravitreal Injections

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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Apr 11, 2018
OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR...
Animals Apoptosis Dose-Response Relationship, Drug Mice Fibrinolytic Agents Cell Proliferation Oxygen Random Allocation Intravitreal Injections Disease Models, Animal Retina Retinal Diseases Mice, Inbred BALB C Microscopy, Electron Xanthophylls Animals, Newborn Hyperoxia In Situ Nick-End Labeling
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Predicting Visual Acuity by Using Machine Learning in Patients Treated for Neovascular Age-Related Macular Degeneration.

Ophthalmology Feb 14, 2018
PURPOSE: To predict, by using machine learning, visual acuity (VA) at 3 and 12 months in patients with neovascular age-related macular degeneration (AMD) after initial upload of 3 anti-vascular endothelial growth factor (VEGF) injections.
Algorithms Databases, Factual Female Reproducibility of Results Aged Aged, 80 and over Male Middle Aged Disease Progression Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Humans Machine Learning Vascular Endothelial Growth Factor A Intravitreal Injections Wet Macular Degeneration Choroidal Neovascularization
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Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Dec 30, 2017
BACKGROUND: To investigate the levels of VEGF in the systemic circulation of patients with type 1 ROP who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB).
Intravitreal Injections Recombinant Fusion Proteins Receptors, Vascular Endothelial Growth Factor Retinopathy of Prematurity Angiogenesis Inhibitors Prognosis Treatment Outcome Female Humans Follow-Up Studies Infant, Newborn Prospective Studies Dose-Response Relationship, Drug Male Biomarkers Vascular Endothelial Growth Factors Time Factors Enzyme-Linked Immunosorbent Assay
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Machine Learning to Analyze the Prognostic Value of Current Imaging Biomarkers in Neovascular Age-Related Macular Degeneration.

Ophthalmology. Retina May 31, 2017
PURPOSE: To evaluate the potential of machine learning to predict best-corrected visual acuity (BCVA) outcomes from structural and functional assessments during the initiation phase in patients receiving standardized ranibizumab therapy for neovascul...
Tomography, Optical Coherence Humans Fundus Oculi Machine Learning Vascular Endothelial Growth Factor A Reproducibility of Results Ranibizumab Prospective Studies Intravitreal Injections Angiogenesis Inhibitors Retinal Pigment Epithelium Prognosis Fluorescein Angiography Treatment Outcome Wet Macular Degeneration Macula Lutea Follow-Up Studies Visual Acuity
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 1, 2025
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
Aged, 80 and over Fluorescein Angiography Male Recombinant Fusion Proteins Middle Aged Humans Follow-Up Studies Wet Macular Degeneration Deep Learning Biomarkers Receptors, Vascular Endothelial Growth Factor Dose-Response Relationship, Drug Angiogenesis Inhibitors Retrospective Studies Visual Acuity Treatment Outcome Female Tomography, Optical Coherence Aged Vascular Endothelial Growth Factor A Intravitreal Injections
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GENERATIVE DEEP LEARNING APPROACH TO PREDICT POSTTREATMENT OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AGE-RELATED MACULAR DEGENERATION AFTER 12 MONTHS.

Retina (Philadelphia, Pa.) Jun 1, 2025
PURPOSE: Predicting long-term anatomical responses in neovascular age-related macular degeneration patients is critical for patient-specific management. This study validates a generative deep learning model to predict 12-month posttreatment optical c...
Retrospective Studies Female Aged Aged, 80 and over Male Deep Learning Time Factors Vascular Endothelial Growth Factor A Humans Angiogenesis Inhibitors Intravitreal Injections Follow-Up Studies Fluorescein Angiography Visual Acuity Macula Lutea Tomography, Optical Coherence Ranibizumab Fundus Oculi Wet Macular Degeneration
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Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method.

Translational vision science & technology Sep 3, 2024
PURPOSE: We evaluated the features predicting visual acuity (VA) after one year in neovascular age-related macular degeneration (nAMD) patients.
Aged, 80 and over Male Middle Aged ROC Curve Angiogenesis Inhibitors Visual Acuity Humans Machine Learning Retrospective Studies Female Aged Wet Macular Degeneration Tomography, Optical Coherence Indocyanine Green Intravitreal Injections Fluorescein Angiography Ranibizumab
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IMPACT OF RESIDUAL SUBRETINAL FLUID VOLUMES ON TREATMENT OUTCOMES IN A SUBRETINAL FLUID-TOLERANT TREAT-AND-EXTEND REGIMEN.

Retina (Philadelphia, Pa.) Nov 1, 2021
PURPOSE: To investigate associations between residual subretinal fluid (rSRF) volumes, quantified using artificial intelligence and treatment outcomes in a subretinal fluid (SRF)-tolerant treat-and-extend (T&E) regimen in neovascular age-related macu...
Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Ranibizumab Wet Macular Degeneration Subretinal Fluid Treatment Outcome Follow-Up Studies Visual Acuity Tomography, Optical Coherence Fundus Oculi Drug Tolerance Humans Artificial Intelligence Prospective Studies Angiogenesis Inhibitors
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Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning: A Post Hoc Analysis of a Randomized Clinical Trial.

JAMA ophthalmology Sep 1, 2020
IMPORTANCE: Large amounts of optical coherence tomographic (OCT) data of diabetic macular edema (DME) are acquired, but many morphologic features have yet to be identified and quantified.
Macular Edema Vascular Endothelial Growth Factor A Intravitreal Injections Recombinant Fusion Proteins Ranibizumab Receptors, Vascular Endothelial Growth Factor Subretinal Fluid Male Middle Aged Deep Learning Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Diabetic Retinopathy Algorithms Retrospective Studies Female Aged Humans
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Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence Tomography.

JAMA ophthalmology Jul 1, 2020
IMPORTANCE: The morphologic changes and their pathognomonic distribution in progressing age-related macular degeneration (AMD) are not well understood.
Disease Progression Angiogenesis Inhibitors Follow-Up Studies Tomography, Optical Coherence Fundus Oculi Artificial Intelligence Retina Prognosis Humans Macular Degeneration Female Intravitreal Injections Aged Fluorescein Angiography Aged, 80 and over Ranibizumab Male Retinal Drusen
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