AIMC Topic: Intravitreal Injections

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Force classification during robotic interventions through simulation-trained neural networks.

International journal of computer assisted radiology and surgery Aug 16, 2019
PURPOSE: Intravitreal injection is among the most frequent treatment strategies for chronic ophthalmic diseases. The last decade has seen a serious increase in the number of intravitreal injections, and with it, adverse effects and drawbacks. To tack...
Swine Image Processing, Computer-Assisted Models, Theoretical Tomography, Optical Coherence Bayes Theorem Robotic Surgical Procedures Intravitreal Injections Diagnostic Techniques, Ophthalmological Mechanical Phenomena Sclera Humans Neural Networks, Computer Machine Learning Computer Simulation Reproducibility of Results Animals
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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Apr 11, 2018
OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR...
Random Allocation Apoptosis Retinal Diseases Intravitreal Injections Animals, Newborn Dose-Response Relationship, Drug Microscopy, Electron Hyperoxia Fibrinolytic Agents Animals In Situ Nick-End Labeling Oxygen Mice Retina Cell Proliferation Xanthophylls Disease Models, Animal Mice, Inbred BALB C
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Predicting Visual Acuity by Using Machine Learning in Patients Treated for Neovascular Age-Related Macular Degeneration.

Ophthalmology Feb 14, 2018
PURPOSE: To predict, by using machine learning, visual acuity (VA) at 3 and 12 months in patients with neovascular age-related macular degeneration (AMD) after initial upload of 3 anti-vascular endothelial growth factor (VEGF) injections.
Algorithms Databases, Factual Female Reproducibility of Results Aged Aged, 80 and over Male Middle Aged Disease Progression Angiogenesis Inhibitors Follow-Up Studies Humans Machine Learning Visual Acuity Vascular Endothelial Growth Factor A Intravitreal Injections Wet Macular Degeneration Choroidal Neovascularization
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Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Dec 30, 2017
BACKGROUND: To investigate the levels of VEGF in the systemic circulation of patients with type 1 ROP who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB).
Intravitreal Injections Recombinant Fusion Proteins Receptors, Vascular Endothelial Growth Factor Retinopathy of Prematurity Angiogenesis Inhibitors Prognosis Treatment Outcome Humans Female Follow-Up Studies Prospective Studies Dose-Response Relationship, Drug Infant, Newborn Biomarkers Vascular Endothelial Growth Factors Male Time Factors Enzyme-Linked Immunosorbent Assay
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Machine Learning to Analyze the Prognostic Value of Current Imaging Biomarkers in Neovascular Age-Related Macular Degeneration.

Ophthalmology. Retina May 31, 2017
PURPOSE: To evaluate the potential of machine learning to predict best-corrected visual acuity (BCVA) outcomes from structural and functional assessments during the initiation phase in patients receiving standardized ranibizumab therapy for neovascul...
Tomography, Optical Coherence Fundus Oculi Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Macula Lutea Humans Reproducibility of Results Machine Learning Ranibizumab Angiogenesis Inhibitors Prospective Studies Retinal Pigment Epithelium Treatment Outcome Prognosis Wet Macular Degeneration Follow-Up Studies Visual Acuity
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 1, 2025
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
Fluorescein Angiography Male Middle Aged Recombinant Fusion Proteins Deep Learning Wet Macular Degeneration Humans Receptors, Vascular Endothelial Growth Factor Angiogenesis Inhibitors Biomarkers Follow-Up Studies Treatment Outcome Retrospective Studies Dose-Response Relationship, Drug Female Visual Acuity Aged Tomography, Optical Coherence Aged, 80 and over Vascular Endothelial Growth Factor A Intravitreal Injections
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GENERATIVE DEEP LEARNING APPROACH TO PREDICT POSTTREATMENT OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AGE-RELATED MACULAR DEGENERATION AFTER 12 MONTHS.

Retina (Philadelphia, Pa.) Jun 1, 2025
PURPOSE: Predicting long-term anatomical responses in neovascular age-related macular degeneration patients is critical for patient-specific management. This study validates a generative deep learning model to predict 12-month posttreatment optical c...
Retrospective Studies Female Aged Aged, 80 and over Male Vascular Endothelial Growth Factor A Deep Learning Intravitreal Injections Fluorescein Angiography Macula Lutea Ranibizumab Humans Wet Macular Degeneration Time Factors Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Tomography, Optical Coherence Fundus Oculi
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Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method.

Translational vision science & technology Sep 3, 2024
PURPOSE: We evaluated the features predicting visual acuity (VA) after one year in neovascular age-related macular degeneration (nAMD) patients.
Male Middle Aged ROC Curve Angiogenesis Inhibitors Visual Acuity Tomography, Optical Coherence Humans Machine Learning Retrospective Studies Female Aged Aged, 80 and over Indocyanine Green Intravitreal Injections Fluorescein Angiography Ranibizumab Wet Macular Degeneration
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IMPACT OF RESIDUAL SUBRETINAL FLUID VOLUMES ON TREATMENT OUTCOMES IN A SUBRETINAL FLUID-TOLERANT TREAT-AND-EXTEND REGIMEN.

Retina (Philadelphia, Pa.) Nov 1, 2021
PURPOSE: To investigate associations between residual subretinal fluid (rSRF) volumes, quantified using artificial intelligence and treatment outcomes in a subretinal fluid (SRF)-tolerant treat-and-extend (T&E) regimen in neovascular age-related macu...
Intravitreal Injections Fluorescein Angiography Ranibizumab Wet Macular Degeneration Subretinal Fluid Drug Tolerance Follow-Up Studies Visual Acuity Tomography, Optical Coherence Fundus Oculi Vascular Endothelial Growth Factor A Humans Artificial Intelligence Prospective Studies Angiogenesis Inhibitors Treatment Outcome
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Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning: A Post Hoc Analysis of a Randomized Clinical Trial.

JAMA ophthalmology Sep 1, 2020
IMPORTANCE: Large amounts of optical coherence tomographic (OCT) data of diabetic macular edema (DME) are acquired, but many morphologic features have yet to be identified and quantified.
Vascular Endothelial Growth Factor A Intravitreal Injections Recombinant Fusion Proteins Ranibizumab Receptors, Vascular Endothelial Growth Factor Subretinal Fluid Middle Aged Deep Learning Angiogenesis Inhibitors Follow-Up Studies Algorithms Visual Acuity Humans Macular Edema Retrospective Studies Diabetic Retinopathy Female Aged Male
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