AIMC Topic: Kidney

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Imaging and spatially resolved mass spectrometry applications in nephrology.

Nature reviews. Nephrology
The application of spatially resolved mass spectrometry (MS) and MS imaging approaches for studying biomolecular processes in the kidney is rapidly growing. These powerful methods, which enable label-free and multiplexed detection of many molecular c...

Design and application of ISSA-BP neural network model for predicting soft tissue relaxation force.

Acta of bioengineering and biomechanics
: Accurate biomechanical modeling is crucial for enhancing the realism of virtual surgical training. This study addressed the computational cost and complexity associated with traditional viscoelastic models by incorporating neural network algorithms...

A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co-exposure.

Ecotoxicology and environmental safety
BACKGROUND: Within the past two decades, high-profile cases of melamine (MA) exposure have raised significant toxicological concerns, particularly regarding food adulteration. While widely used as a fundamental organic chemical intermediate in variou...

Multiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.

Computational biology and chemistry
BACKGROUND: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflamm...

Machine learning selection of basement membrane-associated genes and development of a predictive model for kidney fibrosis.

Scientific reports
This study investigates the role of basement membrane-related genes in kidney fibrosis, a significant factor in the progression of chronic kidney disease that can lead to end-stage renal failure. The authors aim to develop a predictive model using ma...

Deep Learning-Based Tumor Segmentation of Murine Magnetic Resonance Images of Prostate Cancer Patient-Derived Xenografts.

Tomography (Ann Arbor, Mich.)
BACKGROUND/OBJECTIVE: Longitudinal in vivo studies of murine xenograft models are widely utilized in oncology to study cancer biology and develop therapies. Magnetic resonance imaging (MRI) of these tumors is an invaluable tool for monitoring tumor g...

Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights.

Renal failure
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...

Artificial intelligence links CT images to pathologic features and survival outcomes of renal masses.

Nature communications
Treatment decisions for an incidental renal mass are mostly made with pathologic uncertainty. Improving the diagnosis of benign renal masses and distinguishing aggressive cancers from indolent ones is key to better treatment selection. We analyze 132...

A Fully Automated Artificial Intelligence-Based Approach to Predict Renal Function After Radical or Partial Nephrectomy.

Urology
OBJECTIVE: To test if our artificial intelligence (AI)-postoperative glomerular filtration rate (GFR) prediction is as accurate as a validated clinical model. The American Urologic Association recommends estimating postoperative GFR in patients with ...