AIMC Topic: Knowledge Bases
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Knowledge base toward understanding actionable alterations and realizing precision oncology.
International journal of clinical oncology
Dec 12, 2018
In Japan, the National Cancer Center and university hospitals have initiated next-generation sequencing-based in vitro diagnostic testing for cancer patients as a method of clinical sequencing. Based on the molecular alterations detected, physicians ...
A prototype of knowledge-based patient safety event reporting and learning system.
BMC medical informatics and decision making
Dec 7, 2018
BACKGROUND: Patient falls, the most common safety events resulting in adverse patient outcomes, impose significant costs and have become a great burden to the healthcare community. Current patient fall reporting systems remain in the early stage that...
Selecting Test Cases from the Electronic Health Record for Software Testing of Knowledge-Based Clinical Decision Support Systems.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Software testing of knowledge-based clinical decision support systems is challenging, labor intensive, and expensive; yet, testing is necessary since clinical applications have heightened consequences. Thoughtful test case selection improves testing ...
Incorporating Knowledge-Driven Insights into a Collaborative Filtering Model to Facilitate the Differential Diagnosis of Rare Diseases.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Rare diseases, although individually rare, collectively affect one in ten Americans. Because of their rarity, patients with rare diseases are typically left misdiagnosed or undiagnosed, which leads to a prolonged medical journey. The diagnosis pathwa...
Disease comorbidity-guided drug repositioning: a case study in schizophrenia.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
UNLABELLED: The key to any computational drug repositioning is the availability of relevant data in machine-understandable format. While large amount of genetic, genomic and chemical data are publicly available, large-scale higher-level disease and d...
Validation of the Behavior of a Knowledge Base Implementing Clinical Guidelines for Point-of-Care Antiretroviral Toxicity Monitoring.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
This study investigated the automated detection of antiretroviral toxicities in structured electronic health records data. The evaluation compared responses generated by 5 clinical pharmacists and 1 prototype knowledge-based application for 15 random...
Agronomic Linked Data (AgroLD): A knowledge-based system to enable integrative biology in agronomy.
PloS one
Nov 30, 2018
Recent advances in high-throughput technologies have resulted in a tremendous increase in the amount of omics data produced in plant science. This increase, in conjunction with the heterogeneity and variability of the data, presents a major challenge...
Fluid and electrolyte balance-establishing the knowledge base of Foundation Year One doctors.
Irish journal of medical science
Nov 27, 2018
BACKGROUND: Fluid and electrolyte management for hospital inpatients has been identified by multiple reports to be suboptimal, with delegation of this task to the most junior members of a medical team, Foundation Year One (FY1) doctors, also known as...
Assessment of specific versus combined purpose knowledge based models in prostate radiotherapy.
Journal of applied clinical medical physics
Oct 19, 2018
Knowledge-based planning (KBP) can be used to improve plan quality, planning speed, and reduce the inter-patient plan variability. KPB may also identify and reduce systematic variations in VMAT plans, something very important in multi-institutional c...
CamurWeb: a classification software and a large knowledge base for gene expression data of cancer.
BMC bioinformatics
Oct 15, 2018
BACKGROUND: The high growth of Next Generation Sequencing data currently demands new knowledge extraction methods. In particular, the RNA sequencing gene expression experimental technique stands out for case-control studies on cancer, which can be ad...
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