AIMC Topic: Leukemia, Myeloid, Acute
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A novel machine-learning-derived genetic score correlates with measurable residual disease and is highly predictive of outcome in acute myeloid leukemia with mutated NPM1.
Blood cancer journal
Oct 1, 2019
Machine learning applications in the diagnosis of leukemia: Current trends and future directions.
International journal of laboratory hematology
Sep 9, 2019
Machine learning (ML) offers opportunities to advance pathological diagnosis, especially with increasing trends in digitalizing microscopic images. Diagnosing leukemia is time-consuming and challenging in many areas globally and there is a growing tr...
Patient-based prediction algorithm of relapse after allo-HSCT for acute Leukemia and its usefulness in the decision-making process using a machine learning approach.
Cancer medicine
Jul 15, 2019
Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for high-risk acute leukemia (AL), some patients still relapse. Since patients simultaneously have many prognostic factors, difficulties are associated with...
Humans
Machine Learning
Algorithms
Adult
Leukemia, Myeloid, Acute
Male
Middle Aged
Prognosis
Clinical Decision-Making
Female
Young Adult
Disease Management
Models, Theoretical
Hematopoietic Stem Cell Transplantation
Treatment Outcome
Transplantation, Homologous
Decision Trees
Patient Participation
Survival Analysis
Identification of leukemia stem cell expression signatures through Monte Carlo feature selection strategy and support vector machine.
Cancer gene therapy
May 29, 2019
Acute myeloid leukemia (AML) is a type of blood cancer characterized by the rapid growth of immature white blood cells from the bone marrow. Therapy resistance resulting from the persistence of leukemia stem cells (LSCs) are found in numerous patient...
Clinically validated machine learning algorithm for detecting residual diseases with multicolor flow cytometry analysis in acute myeloid leukemia and myelodysplastic syndrome.
EBioMedicine
Oct 22, 2018
BACKGROUND: Multicolor flow cytometry (MFC) analysis is widely used to identify minimal residual disease (MRD) after treatment for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). However, current manual interpretation suffers from dr...
A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia.
Nature communications
Jan 3, 2018
Cancers that appear pathologically similar often respond differently to the same drug regimens. Methods to better match patients to drugs are in high demand. We demonstrate a promising approach to identify robust molecular markers for targeted treatm...
A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.
Haematologica
Dec 14, 2017
Primary therapy resistance is a major problem in acute myeloid leukemia treatment. We set out to develop a powerful and robust predictor for therapy resistance for intensively treated adult patients. We used two large gene expression data sets (n=856...
The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia.
Leukemia
Mar 24, 2017
Recurrent chromosomal abnormalities and gene mutations detected at the time of diagnosis of acute myeloid leukemia (AML) are associated with particular disease features, treatment response and survival of AML patients, and are used to denote specific...
Peripheral FLT-3 ligand levels as a pathobiological parameter duringthe clinical course of acute myeloid leukemia.
Turkish journal of medical sciences
Dec 20, 2016
BACKGROUND/AIM: FLT-3 ligand is a growth factor affecting the hematopoietic lineage. The aim of this study was to evaluate the variability of peripheral FLT-3 ligand during the clinical course of acute myeloid leukemia (AML) patients.
Consistent quantitative gene product expression: #3. Invariance with age.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Oct 18, 2016
The quantitative expression of cell surface antigens and light scattering properties of five cellular reference populations in stressed bone marrow specimens were compared between pediatric and adult patients treated for acute myeloid leukemia (AML)....
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