BACKGROUND: Despite the predictive impact of circulating tumor DNA (ctDNA) minimal residual disease (MRD), accurate prediction of failure risk after curative-intent treatments for early-stage or localized non-small cell lung cancer (NSCLC) patients t...
The simultaneous determination of the expression levels of multiple inflammation-associated cytokines in blood holds great promise for the early screening of cancer including colorectal cancer (CRC). Herein, an antibody microarray-based sandwich meta...
Esophageal adenocarcinoma (EAC) has seen a dramatic rise in incidence in developed countries over the past three decades. Early detection of its precursors-gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and high-grade dysplasia (HG...
Liquid biopsies are transforming oncology, enabling earlier diagnosis, dynamic treatment guidance, and personalized precision medicine, yet current approaches focusing mainly on circulating host cell-free DNA (cfDNA) neglect crucial information withi...
BACKGROUND: Cell-free DNA is a promising source of biomarkers for early cancer detection and carries tumor-driven methylation and fragmentation features that have achieved good diagnostic efficacy across various cancers. However, there were no studie...
Small extracellular vesicles (sEVs) are nanoscale vesicles carrying biomolecules reflective of their cellular origin, making them attractive biomarkers for cancer diagnosis. In this study, we present a high-throughput strategy integrating amphiphile-...
Proceedings of the National Academy of Sciences of the United States of America
Aug 20, 2025
AI is now a cornerstone of modern dataset analysis. In many real world applications, practitioners are concerned with controlling specific kinds of errors, rather than minimizing the overall number of errors. For example, biomedical screening assays ...
Pancreatic cancer (PC) is a highly aggressive malignancy in humans, where early diagnosis significantly improves patient outcomes. However, effective methods for accurate and early detection remain limited. In this multiethnic study involving human s...
Cancer disparities in low- and middle-income countries (LMICs) persist because of socioeconomic inequalities and limited access to screening infrastructure, which requires equitable diagnostic solutions. As researchers, we need to develop interventio...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 29, 2025
Immunotherapy has revolutionized lung cancer treatment, yet predicting patient response remains a challenge. This study used Raman spectroscopy to differentiate between non-small-cell lung cancer patients with short-lasting and long-lasting responses...
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