Cancer is a major public health problem while liver cancer is the main cause of global cancer-related deaths. The previous study demonstrates that the 5-year survival rate for advanced liver cancer is only 30%. Few of the first-line targeted drugs in...
The complementary information found in different modalities of patient data can aid in more accurate modelling of a patient's disease state and a better understanding of the underlying biological processes of a disease. However, the analysis of multi...
Purpose To develop deep learning (DL) radiopathomics models based on contrast-enhanced MRI and pathologic imaging to predict vessels encapsulating tumor clusters (VETC) and survival in hepatocellular carcinoma (HCC). Materials and Methods In this ret...
Journal of the American College of Radiology : JACR
Mar 1, 2025
OBJECTIVE: Hepatocellular carcinoma (HCC) poses a heavy global disease burden; early diagnosis is critical to improve outcomes. Opportunistic screening-the use of imaging data acquired for other clinical indications for disease detection-as well as t...
Liver international : official journal of the International Association for the Study of the Liver
Mar 1, 2025
BACKGROUND & AIMS: Microvascular invasion (MVI) is associated with poor prognosis in hepatocellular carcinoma (HCC). Topology may improve the predictive performance and interpretability of deep learning (DL). We aimed to develop and externally valida...
BACKGROUND: Patients with early-stage hepatocellular carcinoma (HCC) generally have good survival rates following surgical resection. However, a subset of these patients experience recurrence within five years post-surgery.
BACKGROUND: Peritoneal metastasis (PM) after the rupture of hepatocellular carcinoma (HCC) is a critical issue that negatively affects patient prognosis. Machine learning models have shown great potential in predicting clinical outcomes; however, the...
This study aimed to compare image quality and solid focal liver lesion (FLL) assessments between free-breathing, diffusion-weighted imaging using deep learning reconstruction (FB-DL-DWI) and conventional DWI (FB-C-DWI) in patients undergoing clinical...
Combinatorial chemistry & high throughput screening
Jan 1, 2025
BACKGROUND: Necroptosis, a recently identified mechanism of programmed cell death, exerts significant influence on various aspects of cancer biology, including tumor cell proliferation, stemness, metastasis, and immunosuppression. However, the role o...
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