AIMC Topic: Liver

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Patient-specific functional liver segments based on centerline classification of the hepatic and portal veins.

Computer assisted surgery (Abingdon, England)
PURPOSE: Couinaud's liver segment classification has been widely adopted for liver surgery planning, yet its rigid anatomical boundaries often fail to align precisely with individual patient anatomy. This study proposes a novel patient-specific liver...

Integrating spatial and chemical information enhances differentiation of non-alcoholic steatohepatitis states in Raman imaging.

Scientific reports
Machine learning studies for Raman imaging have addressed the differentiability of normal and diseased states in biomedical applications by grouping a set of Raman spectra in terms of spectral similarity over the sample. However, Raman imaging provid...

Integrated multi-omics and machine learning approach reveals the mechanism of nicotinamide alleviating PFOS-induced hepatotoxicity.

Food & function
: Perfluorooctane sulphonate (PFOS) is a persistent environmental contaminant with well-documented hepatotoxic properties. Nicotinamide, the amide derivative of vitamin B3, is widely utilized as a nutritional supplement and exerts multiple biological...

Paired snRNA-seq and scRNA-seq analysis of MASLD patients to identify early-stage markers for disease progression.

Hepatology communications
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide. Progression from simple metabolic dysfunction-associated steatotic liver (MASL) without necro-inflammation to...

Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition.

Hepatology communications
BACKGROUND: Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Ala...

Text to image generators for anatomical illustrations: potential and limitations.

Surgical and radiologic anatomy : SRA
PURPOSE: In recent years, artificial intelligence has made significant advances in medical illustration, paralleling progress in many other fields. These tools provide an efficient and cost-effective approach to creating custom illustrations and rapi...

CLAW-MRM: omprehensive ipidomics utomation orkflow for ultiple eaction onitoring Using Large Language Models.

Analytical chemistry
Lipidomic profiling generates vast datasets, making manual annotation and trend interpretation complex and time-intensive. The structural and chemical diversity of the lipidome further complicates the analysis. While existing tools support targeted l...

Predicting prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure from longitudinal ultrasound images using a multi-task deep learning approach.

Annals of medicine
BACKGROUND: Individualized risk stratification in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) remains challenging. This study aimed to develop and validate a multi-task deep learning model using longitudinal liver ultrasound i...

Serological proteomic characterization for monitoring liver fibrosis regression in chronic hepatitis B patients on treatment.

Nature communications
Longitudinal serological proteomic dynamics during antiviral therapy (AVT) in chronic hepatitis B (CHB) patients with liver fibrosis remain poorly characterized. Here, using four-dimensional data-independent acquisition mass spectrometry (4D-DIA-MS),...

MRI-derived quantification of hepatic vessel-to-volume ratios in chronic liver disease using a deep learning approach.

European radiology experimental
BACKGROUND: We aimed to quantify hepatic vessel volumes across chronic liver disease stages and healthy controls using deep learning-based magnetic resonance imaging (MRI) analysis, and assess correlations with biomarkers for liver (dys)function and ...