BACKGROUND: The development of immunotherapy has provided new hope for patients with advanced gastric cancer (AGC). However, due to the high heterogeneity of the disease, the efficacy of first-line immunochemotherapy varies among patients. There is s...
Environmental geochemistry and health
Dec 22, 2025
Groundwater arsenic contamination poses a significant health risk in coastal region of Bangladesh. However, existing studies have rarely applied advanced machine learning (ML) algorithms to predict arsenic concentrations using comprehensive water qua...
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor survival, driven in part by early metastatic spread. Conventional imaging lacks sufficient precision to predict metastasis accurately. Machine learning (ML)-bas...
Rapid and accurate reconstruction of high-quality three-dimensional magnetic resonance (MR) images from undersampled-space data with variable sampling patterns remains a challenge due to limited available information and the need to preserve rich ana...
With the rapid advancement of information technology, the Internet, as the core infrastructure for global information exchange, faces increasingly severe security challenges. However, traditional network traffic detection methods typically focus sole...
Journal of chemical information and modeling
Dec 21, 2025
Receptor tyrosine kinases (RTKs) are key regulators of cellular functions, such as differentiation, migration and proliferation. Dysregulated RTK activity contributes to various diseases, including neurological disorders and cancer, for which small m...
Journal of chemical information and modeling
Dec 21, 2025
Absorption, distribution, metabolism, and excretion (ADME) properties are among the key factors in determining the success of lead discovery and optimization campaigns. Fast and accurate prediction of molecular ADME profiles is hence of particular in...
Journal of the American Society for Mass Spectrometry
Dec 21, 2025
Recent advances in ion mobility spectrometry have enabled the measurement of rotationally averaged collisional cross-sectional area (CCS) for millions of peptides as part of routine proteomic mass spectrometry workflows. One of the most striking find...
BACKGROUND: Accurate preoperative prediction of pathological complete response (pCR) following neoadjuvant chemoimmunotherapy (nCIT) could help individualize treatment for patients with esophageal squamous cell carcinoma (ESCC). This study aimed to d...
BACKGROUND: Biliary atresia (BA) is a progressive neonatal cholestatic liver disease that requires timely diagnosis and intervention. Differentiating BA from other causes of neonatal cholestasis remains a significant clinical challenge.
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