BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends stepping up to ICS/long-acting mu...
BACKGROUND: Trigeminal activation and sensitisation involved in chronic inflammatory orofacial pain share several similarities with headaches, including migraine. Therefore, understanding the pathophysiological mechanisms is important to determine no...
BACKGROUND: Orthodontically induced root resorption (OIRR) is difficult to assess accurately using traditional 2D imaging due to distortion and low sensitivity. While CBCT offers more precise 3D evaluation, manual segmentation remains labor-intensive...
Nonsyndromic cleft lip with palate (nsCLP) is a common birth defect disease. Current diagnostic methods comprise fetal ultrasound images, which are mainly limited by fetal position and technician skills. We aimed to identify reliable maternal serum l...
BACKGROUND: Myxomatous mitral valve disease (MMVD) represents the most prevalent cardiac disorder in dogs, frequently resulting in mitral regurgitation (MR) and congestive heart failure. Although echocardiography is the gold standard for diagnosis, i...
Supracondylar humerus fractures in children are among the most common elbow fractures in pediatrics. However, their diagnosis can be particularly challenging due to the anatomical characteristics and imaging features of the pediatric skeleton. In rec...
Closed pelvic fractures can lead to severe complications, including hemodynamic instability (HI) and mortality. Accurate prediction of these risks is crucial for effective clinical management. This study aimed to utilize various machine learning (ML)...
SIGNIFICANCE: Automated segmentation of periarterial and perivenous capillary-free zones (CFZs) in optical coherence tomography angiography (OCTA) can significantly improve early detection and monitoring of diabetic retinopathy (DR), a leading cause ...
European journal of drug metabolism and pharmacokinetics
May 8, 2025
BACKGROUND AND OBJECTIVE: Model-informed precision dosing (MIPD), based on a Bayesian approach and machine learning (ML) algorithms, is a suitable approach to personalize dosage recommendations and to improve the concentration target attainment for e...
Digital competence reflects the skills and knowledge needed to thrive in the digital world. Despite the criticality of this concept, the field lacks a robust and valid measure of digital competence that is suitable across the life span. Addressing th...
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