BACKGROUND: Although immune checkpoint inhibitor (ICI) represents a significant breakthrough in cancer immunotherapy, only a few patients benefit from it. Given the critical role of Treg cells in ICI treatment resistance, we explored a Treg-associate...
BACKGROUND: Prognostic histopathological features such as mitosis in melanoma are excluded from the staging systems due to inter-observer variability and time constraints. While digital pathology offers artificial intelligence-driven solutions, exist...
Spatial omics technologies enable analysis of gene expression and interaction dynamics in relation to tissue structure and function. However, existing computational methods may not properly distinguish cellular intrinsic variability and intercellular...
Clinica chimica acta; international journal of clinical chemistry
Mar 25, 2025
A standard for reporting genetic pathology results currently does not exist as a consensus. While effective reports are produced, there is lack of consistency on which details to present or to emphasise, and the ultimate report often reflects an indi...
BACKGROUND: Evidence that artificial intelligence (AI) may improve melanoma detection has led to calls for increased human-AI collaboration in clinical workflows. However, AI-based support may entail a wide range of specific functions for AI. To appr...
ChatGPT is increasingly used in healthcare. Fields like dermatology and radiology could benefit from ChatGPT's ability to help clinicians diagnose skin lesions. This study evaluates the accuracy of ChatGPT in diagnosing melanoma. Our analysis indicat...
The American Journal of dermatopathology
Mar 19, 2025
BACKGROUND: Lymph node (LN) assessment is a critical component in the staging and management of cutaneous melanoma. Traditional histopathological evaluation, supported by immunohistochemical staining, is the gold standard for detecting LN metastases....
Medical & biological engineering & computing
Mar 18, 2025
Skin lesion segmentation is a vital process in skin disease diagnosis, crucial for maintaining diagnostic precision. Despite progress in existing image segmentation methods, challenges remain in handling the fuzzy boundaries of skin lesion areas. To ...
INTRODUCTION: The gut microbiota is associated with the response to immunotherapy in cutaneous melanoma (CM). However, gut fungal biomarkers and bacterial-fungal interactions have yet to be determined.
Skin malignant melanoma is a high-risk tumor with low incidence but high mortality rates. Early detection and treatment are crucial for a cure. Machine learning studies have focused on classifying melanoma tumors, but these methods are cumbersome and...
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