AIMC Topic: Membrane Proteins

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Prediction of ATP-binding sites in membrane proteins using a two-dimensional convolutional neural network.

Journal of molecular graphics & modelling Jul 15, 2019
Membrane proteins, the most important drug targets, account for around 30% of total proteins encoded by the genome of living organisms. An important role of these proteins is to bind adenosine triphosphate (ATP), facilitating crucial biological proce...
Reproducibility of Results ROC Curve Computational Biology Membrane Proteins Neural Networks, Computer Machine Learning Algorithms Binding Sites Amino Acid Motifs Web Browser Position-Specific Scoring Matrices Models, Theoretical Databases, Protein Amino Acid Sequence Adenosine Triphosphate
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Effect of potential probiotic Leuconostoc mesenteroides FB111 in prevention of cholesterol absorption by modulating NPC1L1/PPARĪ±/SREBP-2 pathways in epithelial Caco-2 cells.

International microbiology : the official journal of the Spanish Society for Microbiology Dec 5, 2018
Mustard kimchi consumption reduces cholesterol levels in rats. To identify lactic acid bacteria (LAB) in kimchi which exert this effect, 20 LAB isolates were evaluated for cholesterol reduction in an in vitro screen. The FB111 strain showed the highe...
Epithelial Cells Sterol Regulatory Element Binding Protein 2 Food Microbiology Humans Cholesterol Gene Expression Profiling Probiotics Leuconostoc mesenteroides Real-Time Polymerase Chain Reaction Caco-2 Cells Membrane Transport Proteins Membrane Proteins PPAR alpha
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Higher serum levels of fibroblast growth factor 21 in old patients with cachexia.

Nutrition (Burbank, Los Angeles County, Calif.) Nov 22, 2018
OBJECTIVE: Fibroblast growth factor (FGF)21 is promptly induced by short fasting in animal models to regulate glucose and fat metabolism. Data on FGF21 in humans are inconsistent and FGF21 has not yet been investigated in old patients with cachexia, ...
Pilot Projects Endopeptidases Humans Weight Loss Cachexia Aged Prospective Studies Membrane Proteins Gelatinases Female Aged, 80 and over Fibroblast Growth Factors Serine Endopeptidases Cross-Sectional Studies Male
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Predicting membrane protein types by incorporating a novel feature set into Chou's general PseAAC.

Journal of theoretical biology Jul 27, 2018
Membrane proteins are vital type of proteins that serve as channels, receptors and energy transducers in a cell. They perform various important functions, which are mainly associated with their types. They are also attractive targets of drug discover...
Sequence Analysis, Protein Software Membrane Proteins Support Vector Machine Databases, Protein
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iMem-2LSAAC: A two-level model for discrimination of membrane proteins and their types by extending the notion of SAAC into chou's pseudo amino acid composition.

Journal of theoretical biology Jan 11, 2018
Membrane proteins execute significant roles in cellular processes of living organisms, ranging from cell signaling to cell adhesion. As a major part of a cell, the identification of membrane proteins and their functional types become a challenging jo...
Support Vector Machine Algorithms Databases, Protein Neural Networks, Computer Reproducibility of Results Amino Acid Sequence Computational Biology Sequence Analysis, Protein Membrane Proteins
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The utility of sentinel lymph node mapping in the management of endometrial atypical hyperplasia.

Gynecologic oncology Dec 28, 2017
OBJECTIVES: To determine the risk of endometrial cancer (EC) and lymph node involvement in patients with a preoperative diagnosis of "AH-only" versus "AH - cannot rule out carcinoma" and to study the value of SLN mapping.
Lymph Node Excision Predictive Value of Tests Neoplasm Staging Neoplasm Grading Pelvis Endometrial Neoplasms CA-125 Antigen Carcinoma, Endometrioid Middle Aged Endometrial Hyperplasia Membrane Proteins Humans Myometrium Lymphatic Metastasis Female Neoplasm Invasiveness Sentinel Lymph Node Biopsy Aged Aged, 80 and over Adult Sensitivity and Specificity
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Evaluation of CNTNAP2 gene rs2107856 polymorphism in Turkish population with pseudoexfoliation syndrome.

International ophthalmology Dec 19, 2017
PURPOSE: To investigate rs2107856 single-nucleotide polymorphism (SNP) of CNTNAP2 gene in Turkish population with pseudoexfoliation and to correlate clinical characteristics with the genotypic profile.
Exfoliation Syndrome Turkey Retinal Ganglion Cells Polymerase Chain Reaction Polymorphism, Genetic Visual Acuity Tomography, Optical Coherence DNA Cross-Sectional Studies Intraocular Pressure Male Middle Aged Incidence Genotype Membrane Proteins Prospective Studies Nerve Tissue Proteins Female Humans Aged Aged, 80 and over
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Bi-PSSM: Position specific scoring matrix based intelligent computational model for identification of mycobacterial membrane proteins.

Journal of theoretical biology Sep 18, 2017
Mycobacterium is a pathogenic bacterium, which is a causative agent of tuberculosis (TB) and leprosy. These diseases are very crucial and become the cause of death of millions of people every year in the world. So, the characterize structure of membr...
Membrane Proteins Evolution, Molecular Bacterial Proteins Amino Acid Sequence Artificial Intelligence Computational Biology Mycobacterium Position-Specific Scoring Matrices
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Predicting the helix-helix interactions from correlated residue mutations.

Proteins Aug 24, 2017
Helix-helix interactions are crucial in the structure assembly, stability and function of helix-rich proteins including many membrane proteins. In spite of remarkable progresses over the past decades, the accuracy of predicting protein structures fro...
Computational Biology Membrane Proteins Amino Acid Sequence Binding Sites Machine Learning Protein Binding Protein Interaction Domains and Motifs Protein Conformation, alpha-Helical
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TopologyNet: Topology based deep convolutional and multi-task neural networks for biomolecular property predictions.

PLoS computational biology Jul 27, 2017
UNLABELLED: Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered...
Molecular Dynamics Simulation Protein Folding Neural Networks, Computer Machine Learning Image Processing, Computer-Assisted Protein Binding Computational Biology Membrane Proteins Models, Statistical
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