BACKGROUND: Machine learning models have been successfully applied to neuroimaging data to make predictions about behavioral and cognitive states of interest. While these multivariate methods have greatly advanced the field of neuroimaging, their app...
Insulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear. We assessed insulin resistance using fasting and insulin-stimulated measures in 51 elderly subjects with no dementia (ND; n = 37) and with ...
Neural networks : the official journal of the International Neural Network Society
Jul 1, 2025
Existing deep reinforcement learning (DRL) algorithms suffer from the problem of low sample efficiency. Episodic memory allows DRL algorithms to remember and use past experiences with high return, thereby improving sample efficiency. However, due to ...
How episodic memories are formed in the brain is a continuing puzzle for the neuroscience community. The brain areas that are critical for episodic learning (e.g., the hippocampus) are characterized by recurrent connectivity and generate frequent off...
Cerebral cortex (New York, N.Y. : 1991)
Jun 20, 2023
Successful neuromodulation approaches to alter episodic memory require closed-loop stimulation predicated on the effective classification of brain states. The practical implementation of such strategies requires prior decisions regarding electrode im...
BACKGROUND: Mild cognitive impairment (MCI), which is common in older adults, is a risk factor for dementia. Rapidly growing health care demand associated with global population aging has spurred the development of new digital tools for the assessmen...
Based on whole-brain gray matter volume (GMV), we used relevance vector regression to predict the Rey's Auditory Verbal Learning Test Delayed Recall (AVLT-DR) scores of individual amnestic mild cognitive impairment (aMCI) patient. The whole-brain GMV...
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Apr 29, 2019
From neuroscience, brain imaging and the psychology of memory, we are beginning to assemble an integrated theory of the brain subsystems and pathways that allow the compression, storage and reconstruction of memories for past events and their use in ...
BACKGROUND: Memory dysfunction is characteristic of aging and often attributed to Alzheimer's disease (AD). An easily administered tool for preliminary assessment of memory function and early AD detection would be integral in improving patient manage...
Journal of experimental psychology. General
Jan 1, 2019
Whereas numerous findings support a distinction between episodic and semantic memory, it is now widely acknowledged that these two forms of memory interact during both encoding and retrieval. The precise nature of this interaction, however, remains p...
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