AIMC Topic: Mice
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Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation.
Environmental toxicology
Jul 15, 2015
Polychlorinated biphenyls (PCBs), as typical environmental estrogen disruptors, are a structurally-related group of halogenated aromatic hydrocarbons that are composed of 209 isomers and present as a mixture in the environment. PCBs congener with dif...
Application of comparative biology in GO functional annotation: the mouse model.
Mammalian genome : official journal of the International Mammalian Genome Society
Jul 4, 2015
The Gene Ontology (GO) is an important component of modern biological knowledge representation with great utility for computational analysis of genomic and genetic data. The Gene Ontology Consortium (GOC) consists of a large team of contributors incl...
Computational assignment of cell-cycle stage from single-cell transcriptome data.
Methods (San Diego, Calif.)
Jul 2, 2015
The transcriptome of single cells can reveal important information about cellular states and heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has facilitated expression profiling of large numbers of single cells in para...
Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery.
PLoS neglected tropical diseases
Jun 26, 2015
BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
Analysis of the human diseasome using phenotype similarity between common, genetic, and infectious diseases.
Scientific reports
Jun 8, 2015
Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are s...
Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.
BMC bioinformatics
Jun 6, 2015
BACKGROUND: People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is kn...
Humans
Phenotype
Nerve Tissue Proteins
Models, Molecular
High-Throughput Nucleotide Sequencing
Synapses
Animals
Mice
Genomics
Rats
Cell Adhesion Molecules, Neuronal
Neural Cell Adhesion Molecules
Synaptic Potentials
Calcium-Binding Proteins
Social Behavior
Membrane Potentials
Cell Physiological Phenomena
Autistic Disorder
Gene Ontology
Genome
PsyGeNET: a knowledge platform on psychiatric disorders and their genes.
Bioinformatics (Oxford, England)
May 11, 2015
UNLABELLED: PsyGeNET (Psychiatric disorders and Genes association NETwork) is a knowledge platform for the exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of a database and a web interface supporting data...
Deep convolutional neural networks for annotating gene expression patterns in the mouse brain.
BMC bioinformatics
May 7, 2015
BACKGROUND: Profiling gene expression in brain structures at various spatial and temporal scales is essential to understanding how genes regulate the development of brain structures. The Allen Developing Mouse Brain Atlas provides high-resolution 3-D...
Toll-like receptor signaling in vertebrates: testing the integration of protein, complex, and pathway data in the protein ontology framework.
PloS one
Apr 20, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation o...
Ontology application and use at the ENCODE DCC.
Database : the journal of biological databases and curation
Mar 16, 2015
The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort to create a catalog of genomic annotations. To date, the project has generated over 4000 experiments across more than 350 cell lines and tissues using a wide array o...
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