AIMC Topic: Microfluidic Analytical Techniques

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Implementation of reconfigurable logic-in memory in a cultured neuronal network with a crossbar structure.

Lab on a chip
The concept of logical neural networks, proposed by McCulloch and Pitts, along with Hebb's postulate of learning-specifically, spike-timing-dependent plasticity (STDP), has had a substantial influence on the development of brain-inspired computing re...

Advances in machine learning-enhanced microfluidic cell sorting.

Science advances
Cell sorting, essential for diagnostics and early intervention, has evolved from conventional methods to sophisticated microfluidic approaches. These miniaturized systems leverage precise hydrodynamic control, facilitating major advances in tumor cel...

AI-Assisted Microfluidic Paper-Based Analytical Device with Au-Pt Nanoparticles for Multiplex, Interference-Resistant Quantification of Urinary Biomarkers.

Analytical chemistry
Urinary glucose, creatinine, and uric acid are vital biomarkers for diabetes and kidney disease management. However, multiplex point-of-care detection faces challenges due to insufficient sensitivity in complex urine matrices and signal cross-talk fr...

Transforming microfluidics for single-cell analysis with robotics and artificial intelligence.

Lab on a chip
Single-cell analysis has advanced biomedical research by revealing cellular heterogeneity with unprecedented resolution, identifying rare subpopulations that drive disease progression and therapeutic resistance. Microfluidics is central to this advan...

Label-free phenotypic antimicrobial susceptibility testing on microfluidic platforms: a review of advances and translation.

Mikrochimica acta
The escalating global threat of antimicrobial resistance (AMR) necessitates a paradigm shift towards rapid and scalable diagnostic technologies. Conventional antimicrobial susceptibility testing (AST) methods, while reliable, are hindered by prolonge...

High-resolution time-lapse imaging of droplet-cell dynamics optimal transport and contrastive learning.

Lab on a chip
Single-cell analysis is essential for uncovering heterogeneous biological functions that arise from intricate cellular responses. Here, microfluidic droplet arrays enable high-throughput data collection through cell encapsulation in picoliter volumes...

Analysis of sperm beating characteristics using microfluidic trapping and machine-learning-based flagellum tracking.

Lab on a chip
Male infertility affects a significant portion of couples worldwide, with standard semen analysis often failing to identify functional deficiencies in sperm performance. This study presents a microfluidic platform for characterizing sperm flagellar b...

Smartphone-based biosensing: a review of optical imaging, microfluidic integration, and AI-enhanced analysis.

Mikrochimica acta
Recently, the integration of smartphone-based platforms into biomedical sensing has provided portable, low-cost, and scalable alternatives to conventional laboratory diagnostics. According to the advances in mobile imaging, embedded sensors, microflu...

Self-regulating microfluidic system for lipid nanoparticle production.

Journal of controlled release : official journal of the Controlled Release Society
Lipid nanoparticles have emerged as valuable gene delivery systems paving the way for next-generation vaccine and cancer therapeutics. Inevitably, this evolution is carried by dissecting and rationalizing the vehicles' complex formulation process. Gi...

Darkfield illumination enhancing artificial-intelligence-assisted digital microfluidics for on-site pathogen detection.

Analytica chimica acta
BACKGROUND: Artificial-intelligence (AI) based computer vision emerges as an important part in the digital microfluidic (DMF) system for realization of high-level automatic control of droplets for on-site pathogen detection at the nano-micro scale. H...