AIMC Topic: Multicenter Studies as Topic
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Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case-control development and validation study (COBRA2 study).
BMC cancer
Jul 29, 2025
BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in the United Kingdom. The five-year survival rate from CRC is only 10% when discovered at a late stage, but can exceed 90% if diagnosed early. Symptoms related to CRC can be non-sp...
Evaluating the accuracy of artificial intelligence-powered chest X-ray diagnosis for paediatric pulmonary tuberculosis (EVAL-PAEDTBAID): Study protocol for a multi-centre diagnostic accuracy study.
BMJ open
Jul 28, 2025
INTRODUCTION: Diagnosing pulmonary tuberculosis (PTB) in children is challenging owing to paucibacillary disease, non-specific symptoms and signs and challenges in microbiological confirmation. Chest X-ray (CXR) interpretation is fundamental for diag...
Curating a knowledge base for patients with neurosyphilis: a study protocol of a DEep learning Framework for pErsonalized prediction of Adverse prognosTic events in NeuroSyphilis (DEFEAT-NS).
BMJ open
Jul 18, 2025
INTRODUCTION: Adverse prognostic events (APE) of neurosyphilis include ongoing syphilitic meningitis, meningovascular syphilis, parenchymatous neurosyphilis and death. Its complexity and rarity have the potential to result in the underestimated true ...
Imaging analysis using Artificial Intelligence to predict outcomes after endovascular aortic aneurysm repair: protocol for a retrospective cohort study.
BMJ open
Jul 16, 2025
INTRODUCTION: Endovascular aortic aneurysm repair (EVAR) requires long-term surveillance to detect and treat postoperative complications. However, prediction models to optimise follow-up strategies are still lacking. The primary objective of this stu...
PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders.
BMJ open
Jul 10, 2025
INTRODUCTION: Cognitive behavioural therapy (CBT) serves as a first-line treatment for internalising disorders (ID), encompassing depressive, anxiety or obsessive-compulsive disorders. Nonetheless, a substantial proportion of patients do not experien...
Early warning and stratification of the elderly cardiopulmonary dysfunction-related diseases: multicentre prospective study protocol.
BMJ open
Jul 5, 2025
INTRODUCTION: In China, there is a lack of standardised clinical imaging databases for multidimensional evaluation of cardiopulmonary diseases. To address this gap, this study protocol launched a project to build a clinical imaging technology integra...
A multi-site randomized clinical trial of socially assistive robots on engaging older adults with cognitive impairment residing in long-term care settings: A protocol paper.
Contemporary clinical trials
Jun 6, 2025
Apathy is common in persons with dementias, especially those in long-term care facilities (LTCs). Few pharmacologic options exist; a major strategy is to foster engagement in social, physical, and cognitive activities, but requires extensive personne...
Prenatal detection of congenital heart defects using the deep learning-based image and video analysis: protocol for Clinical Artificial Intelligence in Fetal Echocardiography (CAIFE), an international multicentre multidisciplinary study.
BMJ open
Jun 5, 2025
INTRODUCTION: Congenital heart defect (CHD) is a significant, rapidly emerging global problem in child health and a leading cause of neonatal and childhood death. Prenatal detection of CHDs with the help of ultrasound allows better perinatal manageme...
Active case finding using mobile vans with artificial intelligence aided radiology tests and sputum collection for rapid diagnostic tests to reduce tuberculosis prevalence among high-risk population in rural China: Protocol for a pragmatic trial.
PloS one
Apr 11, 2025
BACKGROUND: Tuberculosis (TB) remains a significant public health challenge, particularly in rural areas of high-burden countries like China. Active case finding (ACF) and timely treatment have been proven effective in reducing TB prevalence, but the...
Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial.
BMJ open
Apr 2, 2025
INTRODUCTION: Membranous nephropathy is an autoimmune kidney disease and the most common cause of nephrotic syndrome in non-diabetic Caucasian adults. Rituximab is now recommended as first-line therapy for membranous nephropathy. However, Kidney Dise...
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