AIMC Topic: Mutagenicity Tests
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Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Aug 13, 2022
2-Methylfuran (2-MF) exists naturally in foods and is used as a flavoring agent. Furan, the core structure of 2-MF, possesses hepatocarcinogenicity in rodents. Accumulation of toxicological information on furan derivatives is needed to elucidate thei...
Prioritization of Mycotoxins Based on Their Genotoxic Potential with an In Silico-In Vitro Strategy.
Toxins
Oct 19, 2021
Humans are widely exposed to a great variety of mycotoxins and their mixtures. Therefore, it is important to design strategies that allow prioritizing mycotoxins based on their toxic potential in a time and cost-effective manner. A strategy combining...
Mining Toxicity Information from Large Amounts of Toxicity Data.
Journal of medicinal chemistry
May 7, 2021
Safety is a main reason for drug failures, and therefore, the detection of compound toxicity and potential adverse effects in the early stage of drug development is highly desirable. However, accurate prediction of many toxicity endpoints is extremel...
The 3D reconstructed skin micronucleus assay using imaging flow cytometry and deep learning: A proof-of-principle investigation.
Mutation research. Genetic toxicology and environmental mutagenesis
Jan 20, 2021
The reconstructed skin micronucleus (RSMN) assay was developed in 2006, as an in vitro alternative for genotoxicity evaluation of dermally applied chemicals or products. In the years since, significant progress has been made in the optimization of th...
Humans
Feasibility Studies
Models, Biological
Tissue Scaffolds
Image Processing, Computer-Assisted
Artificial Intelligence
False Positive Reactions
Predictive Value of Tests
Software
Proof of Concept Study
Flow Cytometry
Mutagenicity Tests
Automation, Laboratory
Micronucleus Tests
Mitomycin
Deep Learning
Skin
Skin, Artificial
In vitro and in silico genetic toxicity screening of flavor compounds and other ingredients in tobacco products with emphasis on ENDS.
Journal of applied toxicology : JAT
Jul 13, 2020
Electronic nicotine delivery systems (ENDS) are regulated tobacco products and often contain flavor compounds. Given the concern of increased use and the appeal of ENDS by young people, evaluating the potential of flavors to induce DNA damage is impo...
Cell Line
Phosphorylation
Models, Molecular
DNA Damage
Animals
Risk Assessment
Mice
Rats
Mutagenicity Tests
Histones
Electronic Nicotine Delivery Systems
Consumer Product Safety
Flow Cytometry
Tumor Suppressor Protein p53
Flavoring Agents
Quantitative Structure-Activity Relationship
Humans
Machine Learning
Biomarkers
Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 1, 2018
Titanium dioxide nanoparticles (TiO-NPs) are widely used in the cosmetics, health, and food industries, but their safety and genotoxicity remain a matter of debate. We investigated whether TiO-NPs could induce gene mutations in mouse lymphoma L5178Y ...
Preservative effect of Camellia sinensis (L.) Kuntze seed extract in soy sauce and its mutagenicity.
Food research international (Ottawa, Ont.)
Nov 23, 2017
The purpose of this study was to investigate the applicability of green tea seed (GTS) extract as a natural preservative in food. Food preservative ability and mutagenicity studies of GTS extract and identification of antimicrobial compounds from GTS...
Distinguishing between expert and statistical systems for application under ICH M7.
Regulatory toxicology and pharmacology : RTP
Jan 3, 2017
Mutagens
Quantitative Structure-Activity Relationship
Drug Contamination
Mutagenicity Tests
Policy Making
Drug and Narcotic Control
Models, Statistical
Data Interpretation, Statistical
Computer Simulation
Molecular Structure
Reproducibility of Results
Expert Systems
Animals
Humans
Risk Assessment
Patient Safety
A knowledge-based expert rule system for predicting mutagenicity (Ames test) of aromatic amines and azo compounds.
Toxicology
Sep 16, 2016
Cancer is one of the main causes of death in Western countries, and a major issue for human health. Prolonged exposure to a number of chemicals was observed to be one of the primary causes of cancer in occupationally exposed persons. Thus, the develo...
Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.
Drug and chemical toxicology
Apr 10, 2016
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...
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