AIMC Topic: Mutation

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Exploring 4 generation EGFR inhibitors: A review of clinical outcomes and structural binding insights.

European journal of pharmacology
Epidermal growth factor receptor (EGFR) is a potential target for anticancer therapies and plays a crucial role in cell growth, survival, and metastasis. EGFR gene mutations trigger aberrant signaling, leading to non-small cell lung cancer (NSCLC). T...

DTreePred: an online viewer based on machine learning for pathogenicity prediction of genomic variants.

BMC bioinformatics
BACKGROUND: A significant challenge in precision medicine is confidently identifying mutations detected in sequencing processes that play roles in disease treatment or diagnosis. Furthermore, the lack of representativeness of single nucleotide varian...

Combining multi-omics analysis with machine learning to uncover novel molecular subtypes, prognostic markers, and insights into immunotherapy for melanoma.

BMC cancer
BACKGROUND: Melanoma (SKCM) is an extremely aggressive form of cancer, characterized by high mortality rates, frequent metastasis, and limited treatment options. Our study aims to identify key target genes and enhance the diagnostic accuracy of melan...

101 Machine Learning Algorithms for Mining Esophageal Squamous Cell Carcinoma Neoantigen Prognostic Models in Single-Cell Data.

International journal of molecular sciences
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors in the digestive tract, characterized by a high recurrence rate and inadequate immunotherapy options. We analyzed mutation data of ESCC from public databases and...

M4: Multi-proxy multi-gate mixture of experts network for multiple instance learning in histopathology image analysis.

Medical image analysis
Multiple instance learning (MIL) has been successfully applied for whole slide images (WSIs) analysis in computational pathology, enabling a wide range of prediction tasks from tumor subtyping to inferring genetic mutations and multi-omics biomarkers...

Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function.

Science China. Life sciences
The vast majority of known viruses belong to the positive-sense single-stranded RNA (+ssRNA) class. Tobamoviruses are among the most destructive plant viruses and threaten global food security. It is generally accepted that +ssRNA viruses including t...

Predictive models of epidermal growth factor receptor mutation in lung adenocarcinoma using PET/CT-based radiomics features.

Medical physics
BACKGROUND: Lung adenocarcinoma (LAC) comprises a substantial subset of non-small cell lung cancer (NSCLC) diagnoses, where epidermal growth factor receptor (EGFR) mutations play a pivotal role as indicators for therapeutic intervention with targeted...

SGCLMD: Signed graph-based contrastive learning model for predicting somatic mutation-drug association.

Computers in biology and medicine
Somatic mutations could influence critical cellular processes, leading to uncontrolled cell growth and tumor formation. Understanding the intricate interactions between somatic mutations and drugs was crucial for advancing our knowledge of the underl...

Enhanced diagnosis of multi-drug-resistant microbes using group association modeling and machine learning.

Nature communications
New solutions are needed to detect genotype-phenotype associations involved in microbial drug resistance. Herein, we describe a Group Association Model (GAM) that accurately identifies genetic variants linked to drug resistance and mitigates false-po...

Brain tumor intelligent diagnosis based on Auto-Encoder and U-Net feature extraction.

PloS one
Preoperative classification of brain tumors is critical to developing personalized treatment plans, however existing classification methods rely on manual intervention and often have problems with efficiency and accuracy, which may lead to misdiagnos...