BACKGROUND: Ultra-early detection of brain injury biomarkers within the critical first hour post-injury remains a major clinical challenge in mild traumatic brain injury (mTBI) management. Conventional platforms (e.g., ELISA) suffer from limited sens...
Micro- and nanoplastics (MNPs) are emerging pollutants that accumulate in ecosystems, food chains, and the human body, raising concerns about human health risks. However, understanding their toxicity remains challenging due to limited experimental da...
Integrating Quality by Design (QbD) principles into nanomedicine development marks a paradigm shift from traditional empirical approaches to more systematic risk-based strategies. This review explores the application of QbD in pharmaceutical nanotech...
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...
Poly(lactide-co-glycolide) (PLGA) nanoparticles are promising drug delivery systems, widely recognized for their ability to overcome various limitations associated with conventional formulations. However, designing and optimizing such formulations is...
Label-free optical imaging of the morphology of single nanoparticles under native conditions remains a challenging task despite its importance in the synthesis, properties, and applications of nanomaterials. Here, we developed an angular scanning dar...
The blood-brain barrier (BBB) poses a major challenge to the effective delivery of therapeutic agents for the treatment of central nervous system (CNS) disorders. The integration of cell membrane engineering with nanotechnology has recently enabled t...
As nanomaterials increasingly interact with complex biological environments, understanding and designing their interfacial layers is critical for enabling functional and responsive behaviors. The protein corona, a spontaneously formed biomolecular la...
Cerebral infarction (CI) is a leading cause of disability and mortality, with activated plasma monocytes and altered protein glycosylation identified as critical contributors to its pathology. However, the mechanisms linking peripheral monocyte activ...
Colorectal cancer remains a major global health challenge, emphasizing the need for advanced diagnostic tools that enable early and accurate detection. Photoacoustic (PA) spectroscopy, a hybrid technique combining optical absorption with acoustic res...
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