AIMC Topic: Neuralgia

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury.

Molecular medicine reports
Spinal cord injury (SCI) represents a notable global health challenge, with neuropathic pain (NP) being a common complication that intensifies patient suffering. Existing research tends to overlook the temporal aspects of NP and fails to offer target...

Multimodal MRI analysis selecting key brain features for machine learning based classification of diabetic neuropathic pain and phenotypes.

Journal of the neurological sciences
Cerebral alterations are associated with diabetic peripheral neuropathy (DPN) and neuropathic pain, including reductions in brain volumes, cortical thickness, sulcus depth, and alterations in metabolites and functional connectivity. This study combin...

Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice.

Science translational medicine
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...

Integrating data mining with transcranial focused ultrasound to refine neuralgia treatment strategies.

Journal of neuroscience methods
BACKGROUND: Neuralgia and other neuropathic pain are difficult to treat owing to their complicated etiology and a wide variety of responses to treatment. The novel neuromodulation technology transcranial focused ultrasound (tFUS) has intriguing impli...

Prediction and validation of anoikis-related genes in neuropathic pain using machine learning.

PloS one
BACKGROUND: Neuropathic pain (NP) can be induced by a variety of clinical conditions, such as spinal cord injury, lumbar disc herniation (LDH), lumbar spinal stenosis, diabetes, herpes zoster, and spinal cord tumors, and inflammatory stimuli. The pat...

Discriminating fingerprints of chronic neuropathic pain following spinal cord injury using artificial neural networks and mass spectrometry analysis of female mice serum.

Neurochemistry international
Spinal cord injury (SCI) often leads to central neuropathic pain, a condition associated with significant morbidity and is challenging in terms of the clinical management. Despite extensive efforts, identifying effective biomarkers for neuropathic pa...

Deep-learning based analysis of in-vivo confocal microscopy images of the subbasal corneal nerve plexus' inferior whorl in patients with neuropathic corneal pain and dry eye disease.

The ocular surface
PURPOSE: To evaluate and compare subbasal corneal nerve parameters of the inferior whorl in patients with dry eye disease (DED), neuropathic corneal pain (NCP), and controls using a novel deep-learning-based algorithm to analyze in-vivo confocal micr...

Brain imaging signatures of neuropathic facial pain derived by artificial intelligence.

Scientific reports
Advances in neuroimaging have permitted the non-invasive examination of the human brain in pain. However, a persisting challenge is in the objective differentiation of neuropathic facial pain subtypes, as diagnosis is based on patients' symptom descr...

Robot-assisted laparoscopic triple neurectomy for chronic inguinal pain: Description of the technique, our experience and preliminary results.

Actas urologicas espanolas
INTRODUCTION: Chronic inguinal pain or inguinodynia following hernioplasty is a relatively common complication that can be very incapacitating. Surgical treatment by triple neurectomy is a therapeutic option when previous treatments (oral/local thera...

Prediction of central neuropathic pain in spinal cord injury based on EEG classifier.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
OBJECTIVES: To create a classifier based on electroencephalography (EEG) to identify spinal cord injured (SCI) participants at risk of developing central neuropathic pain (CNP) by comparing them with patients who had already developed pain and with a...