AIMC Topic: Phenotype

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Breaking the field phenotyping bottleneck in maize with autonomous robots.

Communications biology
Understanding phenotypic plasticity in maize (Zea mays L.) is a current grand challenge for continued crop improvement. Measuring the interactive effects of genetics, environmental factors, and management practices (GxExM) on crop performance is time...

Deep learning-assisted cellular imaging for evaluating acrylamide toxicity through phenotypic changes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Acrylamide (AA), a food hazard generated during thermal processing, poses significant safety risks due to its toxicity. Conventional methods for AA toxicology are time-consuming and inadequate for analyzing cellular morphology. This study developed a...

Evaluation of artificial intelligence robot's knowledge and reliability on dental implants and peri-implant phenotype.

Scientific reports
The aim of this study was to evaluate the reliability and quality of information generated by ChatGPT regarding dental implants and peri-implant phenotypes. A structured questionnaire on these topics was presented to the AI-based chatbot, and its res...

Subphenotyping prone position responders with machine learning.

Critical care (London, England)
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a heterogeneous condition with varying response to prone positioning. We aimed to identify subphenotypes of ARDS patients undergoing prone positioning using machine learning and assess their a...

FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in .

Science advances
There is great interest in using genetically tractable organisms such as to gain insights into the regulation and function of sleep. However, sleep phenotyping in has largely relied on simple measures of locomotor inactivity. Here, we present FlyVI...

Improving genetic variant identification for quantitative traits using ensemble learning-based approaches.

BMC genomics
BACKGROUND: Genome-wide association studies (GWAS) are rapidly advancing due to the improved resolution and completeness provided by Telomere-to-Telomere (T2T) and pangenome assemblies. While recent advancements in GWAS methods have primarily focused...

Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration.

Nature communications
Predicting and quantifying phenotypic consequences of genetic variants in rare disorders is a major challenge, particularly pertinent for 'actionable' genes such as thyroid hormone transporter MCT8 (encoded by the X-linked SLC16A2 gene), where loss-o...

Trans-ancestral rare variant association study with machine learning-based phenotyping for metabolic dysfunction-associated steatotic liver disease.

Genome biology
BACKGROUND: Genome-wide association studies (GWAS) have identified common variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD). However, rare coding variant studies have been limited by phenotyping challenges and ...

Genomic selection in pig breeding: comparative analysis of machine learning algorithms.

Genetics, selection, evolution : GSE
BACKGROUND: The effectiveness of genomic prediction (GP) significantly influences breeding progress, and employing SNP markers to predict phenotypic values is a pivotal aspect of pig breeding. Machine learning (ML) methods are usually used to predict...

Enhancing Bacterial Phenotype Classification Through the Integration of Autogating and Automated Machine Learning in Flow Cytometric Analysis.

Cytometry. Part A : the journal of the International Society for Analytical Cytology
Although flow cytometry produces reliable results, the data processing from gating to fingerprinting is prone to subjective bias. Here, we integrated autogating with Automated Machine Learning in flow cytometry to enhance the classification of bacter...