AIMC Topic: Polysaccharides
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Methyl cellulose/okra mucilage composite films, functionalized with Hypericum perforatum oil and gentamicin, as a potential wound dressing.
International journal of biological macromolecules
Oct 28, 2023
There is a growing demand for the development of functional wound dressings enriched with bioactive natural compounds to improve the quality of life of the population by accelerating the healing process of chronic wounds. In this regard, a functional...
Glycoinformatics in the Artificial Intelligence Era.
Chemical reviews
Aug 12, 2022
Artificial intelligence (AI) methods have been and are now being increasingly integrated in prediction software implemented in bioinformatics and its glycoscience branch known as glycoinformatics. AI techniques have evolved in the past decades, and t...
Artificial intelligence in the analysis of glycosylation data.
Biotechnology advances
Jun 20, 2022
Glycans are complex, yet ubiquitous across biological systems. They are involved in diverse essential organismal functions. Aberrant glycosylation may lead to disease development, such as cancer, autoimmune diseases, and inflammatory diseases. Glycan...
LectinOracle: A Generalizable Deep Learning Model for Lectin-Glycan Binding Prediction.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 4, 2021
Ranging from bacterial cell adhesion over viral cell entry to human innate immunity, glycan-binding proteins or lectins are abound in nature. Widely used as staining and characterization reagents in cell biology and crucial for understanding the inte...
Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway.
Journal of ethnopharmacology
Oct 6, 2021
ETHNOPHARMACOLOGICAL RELEVANCE: Mulberry leaves have been used as traditional hypoglycemic medicine-food plant for thousand years in China. According to traditional Chinese medicine theory, type 2 diabetes mellitus (T2DM) belongs to the category of X...
Glycation End Products, Advanced
Receptor for Advanced Glycation End Products
Morus
Alkaloids
3T3-L1 Cells
NF-kappa B
p38 Mitogen-Activated Protein Kinases
Polysaccharides
Mice
Plant Extracts
Hypoglycemic Agents
Flavonoids
Diabetes Mellitus, Experimental
Hep G2 Cells
Plant Leaves
Humans
Animals
Male
Diabetes Mellitus, Type 2
Deep-Learning Resources for Studying Glycan-Mediated Host-Microbe Interactions.
Cell host & microbe
Oct 28, 2020
Glycans, the most diverse biopolymer, are shaped by evolutionary pressures stemming from host-microbe interactions. Here, we present machine learning and bioinformatics methods to leverage the evolutionary information present in glycans to gain insig...
Enhanced Fermentable Sugar Production from Enteromorpha Polysaccharides by the Crude Enzymes of Vibrio sp. H11.
Journal of molecular microbiology and biotechnology
Mar 6, 2020
In recent years, large-scale outbreaks of the green alga Enteromorpha prolifera in China's offshore waters have posed a serious threat. This study aimed to improve Enteromorpha polysaccharide (EP) enzymatic sugar production using the hydrolase system...
Non-invasive diagnosis of non-alcoholic steatohepatitis and fibrosis with the use of omics and supervised learning: A proof of concept study.
Metabolism: clinical and experimental
Nov 9, 2019
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects 25-30% of the general population and is characterized by the presence of non-alcoholic fatty liver (NAFL) that can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis and cirr...
Alkaline conditions better extract anti-inflammatory polysaccharides from winemaking by-products.
Food research international (Ottawa, Ont.)
Jul 3, 2019
Winemaking generates large amounts of by-products, a well recognized source of phenolic compounds. However, less attention has been paid to the polysaccharide-rich fraction (PRF) and effects of fractionation techniques on its potential bioactivity. T...
Focusing aptamer selection on the glycan structure of prostate-specific antigen: Toward more specific detection of prostate cancer.
Biosensors & bioelectronics
Dec 26, 2018
The development of chemical sensors capable of detecting the specific glycosylation patterns of proteins offers a powerful mean for the early detection of cancer. Unfortunately, this strategy is scarcely explored because receptors recognizing the gly...
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