AIMC Topic: Precision Medicine

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A Computational Framework for Tailored Preventive Care Recommendations Using Electronic Health Records.

Studies in health technology and informatics
Most healthcare systems worldwide are designed to be reactive. According to the U.S. Centers for Disease Control and Prevention (CDC), 90% of the nation's $3.3 trillion annual healthcare expenditures are attributed to individuals with chronic and men...

Type 2 Diabetes Subtyping via Phenotype and Genotype Co-Learning.

Studies in health technology and informatics
Interpreting and subtyping type 2 diabetes (T2D) is challenging yet essential for achieving fine-grained pathophysiological insights and precise clinical stratification. Previous studies have primarily relied on a small number of pre-selected risk fa...

Single-cell omics: moving towards a new era in ischemic stroke research.

European journal of pharmacology
Ischemic stroke (IS) is a highly complex and heterogeneous disease involving multiple pathophysiological events. A better understanding of the pathophysiology of IS will enhance preventive, diagnostic and therapeutic strategies. Despite significant a...

Charting New Paths in Cancer Research: Insights from the Frontiers in Cancer Science Conference 2024.

Cancer research
The 16th annual Frontiers in Cancer Science conference convened leading experts to discuss the latest developments in cancer research. Key research themes included mechanisms of treatment resistance and innovative strategies to target resistant cance...

A solution to the postantibiotic era: phages as precision medicine.

Current opinion in microbiology
Antibiotic-resistant bacterial infections pose a significant global health challenge. Phage therapy provides a promising alternative to antibiotics that enables the specific targeting of pathogenic bacteria while preserving the healthy microbiome. Re...

Towards precision medicine in antiphospholipid syndrome.

The Lancet. Rheumatology
Antiphospholipid syndrome is a rare systemic autoimmune disorder with complex pathophysiology and high heterogeneity in clinical presentation and treatment responses. The core idea of precision medicine is that the varying treatment responses among p...

The Role of Digital Technologies in Personalized Craniomaxillofacial Surgical Procedures.

Oral and maxillofacial surgery clinics of North America
Craniomaxillofacial (CMF) surgery addresses complex challenges, balancing aesthetic and functional restoration. Digital technologies, including advanced imaging, virtual surgical planning, computer-aided design, and 3D printing, have revolutionized t...

Evaluating prediction of short-term tolerability of five type 2 diabetes drug classes using routine clinical features: UK population-based study.

Diabetes, obesity & metabolism
AIMS: A precision medicine approach in type 2 diabetes (T2D) needs to consider potential treatment risks alongside established benefits for glycaemic and cardiometabolic outcomes. Considering five major T2D drug classes, we aimed to describe variatio...

From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease.

Clinical nutrition ESPEN
Inflammatory bowel disease (IBD), comprising ulcerative colitis and Crohn's disease, is a chronic inflammatory condition with global prevalence and varying incidence. The IBD pathogenesis involves intricate interactions among genetic, host and enviro...

Large models in medical imaging: Advances and prospects.

Chinese medical journal
Recent advances in large models demonstrate significant prospects for transforming the field of medical imaging. These models, including large language models, large visual models, and multimodal large models, offer unprecedented capabilities in proc...