AIMC Topic: Proof of Concept Study

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Machine learning-assisted neurotoxicity prediction in human midbrain organoids.

Parkinsonism & related disorders May 8, 2020
INTRODUCTION: Brain organoids are highly complex multi-cellular tissue proxies, which have recently risen as novel tools to study neurodegenerative diseases such as Parkinson's disease (PD). However, with increasing complexity of the system, usage of...
Induced Pluripotent Stem Cells Oxidopamine Organoids Mesencephalon Humans Machine Learning Proof of Concept Study Dopaminergic Neurons Neurotoxicity Syndromes Microscopy, Confocal Flow Cytometry
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A new lower limb portable exoskeleton for gait assistance in neurological patients: a proof of concept study.

Journal of neuroengineering and rehabilitation May 6, 2020
BACKGROUND: Few portable exoskeletons following the assist-as-needed concept have been developed for patients with neurological disorders. Thus, the main objectives of this proof-of-concept study were 1) to explore the safety and feasibility of an ex...
Humans Algorithms Female Adult Cross-Sectional Studies Proof of Concept Study Exoskeleton Device Physical Therapy Modalities Stroke Rehabilitation Gait Disorders, Neurologic Male Middle Aged Robotics Multiple Sclerosis
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A proof of concept machine learning analysis using multimodal neuroimaging and neurocognitive measures as predictive biomarker in bipolar disorder.

Asian journal of psychiatry Feb 26, 2020
BACKGROUND: Concomitant use of complementary, multimodal imaging measures and neurocognitive measures is reported to have higher accuracy as a biomarker in Alzheimer's dementia. However, such an approach has not been examined to differentiate healthy...
Proof of Concept Study Executive Function Reproducibility of Results Young Adult Sensitivity and Specificity Male Support Vector Machine Magnetic Resonance Imaging Neuroimaging Psychiatric Status Rating Scales Bipolar Disorder Machine Learning Humans Biomarkers Brain Female
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Robot-assisted arm training for treating adult patients with distal radius fracture: a proof-of-concept pilot study.

European journal of physical and rehabilitation medicine Feb 25, 2020
BACKGROUND: Fracture of the distal radius is a common wrist injury. As to its management after orthopedic (conservative or surgical) treatment, there is weak evidence for conventional rehabilitation interventions. Despite the increasing interest for ...
Hand Strength Robotics Single-Blind Method Exercise Therapy Radius Fractures Range of Motion, Articular Proof of Concept Study Aged Male Middle Aged Pilot Projects Humans Female
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Same same but different: A Web-based deep learning application revealed classifying features for the histopathologic distinction of cortical malformations.

Epilepsia Feb 20, 2020
OBJECTIVE: The microscopic review of hematoxylin-eosin-stained images of focal cortical dysplasia type IIb and cortical tuber of tuberous sclerosis complex remains challenging. Both entities are distinct subtypes of human malformations of cortical de...
ROC Curve Area Under Curve Epilepsy Internet Algorithms Reproducibility of Results Diagnosis, Computer-Assisted Deep Learning Neuropathology Tuberous Sclerosis Neurons Cerebral Cortex Proof of Concept Study Malformations of Cortical Development, Group I Humans Neural Networks, Computer
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A machine learning approach for handling big data produced by high resolution mass spectrometry after data independent acquisition of small molecules - Proof of concept study using an artificial neural network for sample classification.

Drug testing and analysis Feb 6, 2020
Liquid chromatography coupled to high-resolution mass spectrometry (HRMS) enables data independent acquisition (DIA) and untargeted screening. However, to avoid the handling of the resulting large dataset, most laboratories in that field still use ta...
Humans Neural Networks, Computer Machine Learning Chromatography, Liquid Cocaine Substance Abuse Detection Zolpidem Proof of Concept Study Small Molecule Libraries Reproducibility of Results Sensitivity and Specificity Big Data Mass Spectrometry
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FastEmbed: Predicting vulnerability exploitation possibility based on ensemble machine learning algorithm.

PloS one Feb 6, 2020
In recent years, the number of vulnerabilities discovered and publicly disclosed has shown a sharp upward trend. However, the value of exploitation of vulnerabilities varies for attackers, considering that only a small fraction of vulnerabilities are...
Algorithms Forecasting Confidentiality Proof of Concept Study Data Collection Machine Learning Computer Security Information Systems Risk-Taking
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Use of Artificial Intelligence-Based Analytics From Live Colonoscopies to Optimize the Quality of the Colonoscopy Examination in Real Time: Proof of Concept.

Gastroenterology Jan 13, 2020
Datasets as Topic Proof of Concept Study Deep Learning Mass Screening Rectum Image Interpretation, Computer-Assisted Humans Colorectal Neoplasms Prospective Studies Colon Colonoscopy
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Automated tracheal intubation in an airway manikin using a robotic endoscope: a proof of concept study.

Anaesthesia Jan 3, 2020
Robotic endoscope-automated via laryngeal imaging for tracheal intubation (REALITI) has been developed to enable automated tracheal intubation. This proof-of-concept study using a convenience sample of participants, comprised of trained anaesthetists...
Young Adult Adult Male Clinical Competence Robotics Video Recording Proof of Concept Study User-Computer Interface Humans Time Factors Manikins Female Intubation, Intratracheal Laryngoscopes
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Enhanced Diagnosis of Severe Aortic Stenosis Using Artificial Intelligence: A Proof-of-Concept Study of 530,871 Echocardiograms.

JACC. Cardiovascular imaging Dec 18, 2019
Predictive Value of Tests Image Interpretation, Computer-Assisted Proof of Concept Study Female Male Diagnosis, Computer-Assisted Humans Aged Ventricular Function, Left Artificial Intelligence Aortic Valve Stenosis Severity of Illness Index Echocardiography Aged, 80 and over Databases, Factual Aortic Valve Hemodynamics Middle Aged Prognosis Adult
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