AIMC Topic: Pyridines
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A Deep Neural Network for the Rapid Prediction of X-ray Absorption Spectra.
The journal of physical chemistry. A
May 18, 2020
X-ray spectroscopy delivers strong impact across the physical and biological sciences by providing end users with highly detailed information about the electronic and geometric structure of matter. To decode this information in challenging cases, , ...
Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.
Drug metabolism and pharmacokinetics
Oct 25, 2019
BACKGROUND: The anticoagulant actions of oral direct factor Xa (FXa) inhibitors can be inferred from their observed plasma concentrations; however, the steady-state pharmacokinetics (PK) of different FXa inhibitors have not been compared in clinicall...
Synthesis of Patient-Specific Transmission Data for PET Attenuation Correction for PET/MRI Neuroimaging Using a Convolutional Neural Network.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Aug 30, 2018
Attenuation correction is a notable challenge associated with simultaneous PET/MRI, particularly in neuroimaging, where sharp boundaries between air and bone volumes exist. This challenge leads to concerns about the visual and, more specifically, qua...
Desert actinobacteria as a source of bioactive compounds production with a special emphases on Pyridine-2,5-diacetamide a new pyridine alkaloid produced by Streptomyces sp. DA3-7.
Microbiological research
Nov 21, 2017
In the present study, 134 morphologically distinct actinobacteria isolates were obtained from soil samples from 10 different localities in the Saudi Arabian desert. The preliminary screening revealed that 16 of these isolates possessed antimicrobial ...
Alkaloids
Cryptococcus neoformans
Desert Climate
Breast Neoplasms
Humans
Antineoplastic Agents
Cell Line, Tumor
Soil Microbiology
Anti-Infective Agents
Saudi Arabia
Salmonella typhimurium
Microbial Sensitivity Tests
Adenocarcinoma
Female
Pyridines
Escherichia coli
MCF-7 Cells
Streptomyces
Enterococcus faecalis
Simultaneous quantification of batrachotoxin and epibatidine in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.
Legal medicine (Tokyo, Japan)
Dec 22, 2016
An ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous quantification of batrachotoxin and epibatidine in plasma. Plasma samples were pretreated by liquid-liquid extrac...
The safety and efficacy of full- versus reduced-dose betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention With Extended-Duration Betrixaban (APEX) trial.
American heart journal
Dec 18, 2016
BACKGROUND: The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg ...
Edoxaban vs warfarin in patients with nonvalvular atrial fibrillation in the US Food and Drug Administration approval population: An analysis from the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) trial.
American heart journal
Dec 1, 2015
BACKGROUND: Edoxaban is a specific anti-Xa inhibitor that, in comparison to warfarin, has been found to be noninferior for the prevention of stroke or systemic embolism (SSE) and to reduce bleeding significantly in patients with nonvalvular atrial fi...
Thiazoles
Factor Xa
Factor Xa Inhibitors
Drug Approval
Warfarin
Stroke
Myocardial Infarction
Atrial Fibrillation
United States Food and Drug Administration
Thrombolytic Therapy
Anticoagulants
Blood Coagulation
Double-Blind Method
Humans
Female
Aged
Male
United States
Dose-Response Relationship, Drug
Pyridines
Drug-Drug interactions and special considerations in breast cancer patients treated with CDK4/6 inhibitors: A comprehensive review.
Cancer treatment reviews
Jun 1, 2025
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have reshaped the treatment paradigm of hormone receptor positive (HR + )/HER2-negative breast cancer in both adjuvant and metastatic settings. However, their metabolism via the cytochrome P450 (CYP3A4...
A Deep Learning-Enabled Workflow to Estimate Real-World Progression-Free Survival in Patients With Metastatic Breast Cancer: Study Using Deidentified Electronic Health Records.
JMIR cancer
May 15, 2025
BACKGROUND: Progression-free survival (PFS) is a crucial endpoint in cancer drug research. Clinician-confirmed cancer progression, namely real-world PFS (rwPFS) in unstructured text (ie, clinical notes), serves as a reasonable surrogate for real-worl...
Predicting transcriptional changes induced by molecules with MiTCP.
Briefings in bioinformatics
Nov 22, 2024
Studying the changes in cellular transcriptional profiles induced by small molecules can significantly advance our understanding of cellular state alterations and response mechanisms under chemical perturbations, which plays a crucial role in drug di...
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