AIMC Topic: Randomized Controlled Trials as Topic

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Large Language Model-Assisted Risk-of-Bias Assessment in Randomized Controlled Trials Using the Revised Risk-of-Bias Tool: Usability Study.

Journal of medical Internet research
BACKGROUND: The revised Risk-of-Bias tool (RoB2) overcomes the limitations of its predecessor but introduces new implementation challenges. Studies demonstrate low interrater reliability and substantial time requirements for RoB2 implementation. Larg...

Enhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention.

BMJ open
INTRODUCTION: Psychosis, characterised by chronic symptoms often emerging in youth, imposes a substantial burden on individuals and healthcare systems. While early detection and intervention can mitigate this burden, there is limited evidence on the ...

AI-empowered health coaching for university students: A mixed-method process evaluation.

Computers in biology and medicine
BACKGROUND: Artificial Intelligence (AI)-empowered health coaching (HC) has the potential to enhance HC effectiveness by providing real-time, evidence-based support. However, integrating AI into live HC sessions presents challenges, particularly in r...

A multi-site randomized clinical trial of socially assistive robots on engaging older adults with cognitive impairment residing in long-term care settings: A protocol paper.

Contemporary clinical trials
Apathy is common in persons with dementias, especially those in long-term care facilities (LTCs). Few pharmacologic options exist; a major strategy is to foster engagement in social, physical, and cognitive activities, but requires extensive personne...

Enriching patient populations in ICU trials: reducing heterogeneity through machine learning.

Current opinion in critical care
PURPOSE OF REVIEW: Despite the pivotal role of randomized controlled trials (RCTs) in critical care research, many have failed to demonstrate significant benefits, particularly in nutrition interventions. This review highlights how patient heterogene...

Predicting treatment outcome for complex posttraumatic stress disorder using the personalized advantage index.

European journal of psychotraumatology
Ample studies have demonstrated the effectiveness of psychotherapy for posttraumatic stress disorder (PTSD). However, large individual variation in treatment outcome remains unsolved and treatment options for complex posttraumatic stress disorder (C...

Exercise Therapy in Down Syndrome: A Systematic Review and Meta-Analysis Focused on Muscle Strength, Redox Balance, and Inflammatory Profile.

Medicine and science in sports and exercise
OBJECTIVE: This study systematically reviewed and meta-analyzed randomized and quasi-randomized controlled trials investigating the impact of exercise therapy on muscle strength, redox balance, and inflammatory profile in individuals with Down syndro...

Recent advances in therapeutic probiotics: insights from human trials.

Clinical microbiology reviews
SUMMARYRecent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome's role in health and disease. However, comprehensive reviews integrating the di...