AIMC Topic: Rats, Sprague-Dawley

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An efficient method for building a database of diatom populations for drowning site inference using a deep learning algorithm.

International journal of legal medicine Jan 3, 2021
Seasonal or monthly databases of the diatom populations in specific bodies of water are needed to infer the drowning site of a drowned body. However, existing diatom testing methods are laborious, time-consuming, and costly and usually require specif...
Databases, Factual Sensitivity and Specificity Animals Lung Neural Networks, Computer Artificial Intelligence Rivers Models, Animal Diatoms Forensic Pathology Drowning China Rats Rats, Sprague-Dawley Seasons
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Comprehensive evaluation of the combined extracts of Epimedii Folium and Ligustri Lucidi Fructus for PMOP in ovariectomized rats based on MLP-ANN methods.

Journal of ethnopharmacology Nov 8, 2020
ETHNOPHARMACOLOGICAL RELEVANCE: Kidney deficiency is the main pathogenesis of osteoporosis based on the theory of "kidney governing bones" in traditional Chinese medicine (TCM). Osteoporosis is a systemic disease; kidney deficiency influences the gro...
X-Ray Microtomography Ligustrum Animals Ovariectomy Rats Rats, Sprague-Dawley Drugs, Chinese Herbal Drug Evaluation, Preclinical Fruit Osteoporosis, Postmenopausal Humans Neural Networks, Computer Bone Density Female
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Scattering Signatures of Normal versus Abnormal Livers with Support Vector Machine Classification.

Ultrasound in medicine & biology Sep 8, 2020
Fifty years of research on the nature of backscatter from tissues has resulted in a number of promising diagnostic parameters. We recently introduced two analyses tied directly to the biophysics of ultrasound scattering: the H-scan, based on a matche...
Animals Male Ultrasonography Rats Support Vector Machine Rats, Sprague-Dawley Liver Liver Diseases
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Exploration of the mechanism of traditional Chinese medicine by AI approach using unsupervised machine learning for cellular functional similarity of compounds in heterogeneous networks, XiaoErFuPi granules as an example.

Pharmacological research Jul 17, 2020
'Polypharmacology' is usually used to describe the network-wide effect of a single compound, but traditional Chinese medicine (TCM) has a polypharmacological effect naturally based on the 'multi-components, multi-targets and multi-pathways' principle...
Polypharmacology Dyspepsia Signal Transduction Medicine, Chinese Traditional Rats, Sprague-Dawley Cluster Analysis Unsupervised Machine Learning Structure-Activity Relationship Molecular Structure Drugs, Chinese Herbal Systems Biology Duodenum Proteomics Proteome Gene Expression Profiling Transcriptome Protein Interaction Maps Gene Regulatory Networks Humans Animals Male
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Machine learning-based segmentation of ischemic penumbra by using diffusion tensor metrics in a rat model.

Journal of biomedical science Jul 15, 2020
BACKGROUND: Recent trials have shown promise in intra-arterial thrombectomy after the first 6-24 h of stroke onset. Quick and precise identification of the salvageable tissue is essential for successful stroke management. In this study, we examined t...
Animals Male ROC Curve Rats Machine Learning Algorithms Diffusion Tensor Imaging Rats, Sprague-Dawley Disease Models, Animal Infarction, Middle Cerebral Artery Ischemia
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Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay.

Molecular pharmaceutics Jun 12, 2020
The in vitro-in vivo extrapolation (IVIVE) approach for predicting total plasma clearance (CL) has been widely used to rank order compounds early in discovery. More recently, a computational machine learning approach utilizing physicochemical descrip...
Humans Machine Learning Animals Male Protein Binding Rats Rats, Sprague-Dawley Permeability Pharmacokinetics Administration, Intravenous Plasma Metabolic Clearance Rate Models, Biological Membranes, Artificial Madin Darby Canine Kidney Cells Microsomes, Liver Hepatocytes Liver Blood Proteins Pharmaceutical Preparations Dogs
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Bioinspired Soft Robot with Incorporated Microelectrodes.

Journal of visualized experiments : JoVE Feb 28, 2020
Bioinspired soft robotic systems that mimic living organisms using engineered muscle tissue and biomaterials are revolutionizing the current biorobotics paradigm, especially in biomedical research. Recreating artificial life-like actuation dynamics i...
Myocardial Contraction Myocytes, Cardiac Tissue Engineering Tissue Scaffolds Microelectrodes Hydrogels Biocompatible Materials Biomimetics Nanotubes, Carbon Rats Rats, Sprague-Dawley Robotics Myocardium Polyethylene Glycols Animals
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Growth Factor Delivery for the Repair of a Critical Size Tibia Defect Using an Acellular, Biodegradable Polyethylene Glycol-Albumin Hydrogel Implant.

ACS biomaterials science & engineering Nov 5, 2019
Growth factor delivery using acellular matrices presents a promising alternative to current treatment options for bone repair in critical-size injuries. However, supra-physiological doses of the factors can introduce safety concerns that must be alle...
Tibia Albumins Hydrogels Intercellular Signaling Peptides and Proteins Absorbable Implants Animals Rats Rats, Sprague-Dawley Polyethylene Glycols
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Ovarian Toxicity Assessment in Histopathological Images Using Deep Learning.

Toxicologic pathology Oct 8, 2019
As ovarian toxicity is often a safety concern for cancer therapeutics, identification of ovarian pathology is important in early stages of preclinical drug development, particularly when the intended patient population include women of child-bearing ...
Female Animals Deep Learning Image Processing, Computer-Assisted Retrospective Studies Rats Rats, Sprague-Dawley Corpus Luteum
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Responses of midbrain auditory neurons to two different environmental sounds-A new approach on cross-sound modeling.

Bio Systems Sep 28, 2019
When modeling auditory responses to environmental sounds, results are satisfactory if both training and testing are restricted to datasets of one type of sound. To predict 'cross-sound' responses (i.e., to predict the response to one type of sound e....
Acoustic Stimulation Evoked Potentials, Auditory, Brain Stem Inferior Colliculi Neural Networks, Computer Animals Rats Systems Biology Rats, Sprague-Dawley Models, Biological Neurons
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