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Rats, Wistar

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The Effects of Topical Burow's and Castellani's Solutions on the Middle Ear Mucosa of Rats.

The journal of international advanced otology
OBJECTIVE: The aim of this study is to investigate the early histopathologic effects of Burow's and Castellani's solutions on the middle ear mucosa of rats.

Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity.

The journal of international advanced otology
OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in verte...

Extracted Anaxagorea luzonensis A. Gray Restored Impairment of Endothelium-Dependent Vasorelaxation Induced by Homocysteine Thiolactone in Rat Aortic Rings.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet
OBJECTIVE: To investigate the beneficial effects of Anaxagorea luzonensis (AL) extract on homocysteine thiolactone (HTL)-induced impairment of endothelium-dependent relaxation in rat aortic rings. The mechanisms involved in the effects of AL on endot...

[Biotransformation and safety of cotton stalk alkaline peroxide mechanical pulping waste liquor].

Wei sheng wu xue bao = Acta microbiologica Sinica
OBJECTIVE: We studied the conditions of culturing Bacillus subtilis SY1 to treat cotton stalk alkaline peroxide mechanical pulping waste water, and evaluated afterwards the safety of its release to plants and animals.

Physicochemical properties and biological evaluation of Yoyo bitters.

African journal of medicine and medical sciences
BACKGROUND: The current widespread distribution and use of Yoyo bitters; an herbal bitters made in Nigeria calls for an assessment of its content, efficacy and extent to which this product achieves the labelled claim of being an herbal cleanser.

Effect of Mast Cell Chymase on Activation, Proliferation and Transdifferentiation of Hepatic Stellate Cells.

Hepato-gastroenterology
BACKGROUND/AIMS: This work aims to observe the effects of mast cell (MC) chymase on activation, proliferation and transdifferentiation of hepatic stellate cells (HSCs) and to discuss the role of chymase in development of liver fibrosis.

Design, Synthesis and Biological Evaluation of New Thieno[2,3- d]pyrimidines as Anti-inflammatory Agents.

Anti-inflammatory & anti-allergy agents in medicinal chemistry
BACKGROUND: Long term use of NSAIDS is mainly accompanied by major health implications such as gastrointestinal erosions, ulcerations and nephrotoxicity. These side effects arise from local irritation by the carboxylic acid moiety, that is common to ...

Paclitaxel-loaded niosomes for intravenous administration: pharmacokinetics and tissue distribution in rats.

Turkish journal of medical sciences
BACKGROUND/AIM: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats.

Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences.

Turkish journal of medical sciences
BACKGROUND/AIM: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and ass...