AIMC Topic: RNA, Messenger
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Predicting humoral responses to primary and booster SARS-CoV-2 mRNA vaccination in people living with HIV: a machine learning approach.
Journal of translational medicine
May 7, 2024
BACKGROUND: SARS-CoV-2 mRNA vaccines are highly immunogenic in people living with HIV (PLWH) on effective antiretroviral therapy (ART). However, whether viro-immunologic parameters or other factors affect immune responses to vaccination is debated. T...
mRNA-CLA: An interpretable deep learning approach for predicting mRNA subcellular localization.
Methods (San Diego, Calif.)
May 3, 2024
Messenger RNA (mRNA) is vital for post-transcriptional gene regulation, acting as the direct template for protein synthesis. However, the methods available for predicting mRNA subcellular localization need to be improved and enhanced. Notably, few ex...
Identifying lncRNAs and mRNAs related to survival of NSCLC based on bioinformatic analysis and machine learning.
Aging
May 1, 2024
Non-small cell lung cancer (NSCLC) is the most common histopathological type, and it is purposeful for screening potential prognostic biomarkers for NSCLC. This study aims to identify the lncRNAs and mRNAs related to survival of non-small cell lung c...
Developing an interpretation model for body fluid identification.
Forensic science international
Apr 22, 2024
Criminal investigations, particularly sexual assaults, frequently require the identification of body fluid type in addition to body fluid donor to provide context. In most cases this can be achieved by conventional methods, however, in certain scenar...
TEC-miTarget: enhancing microRNA target prediction based on deep learning of ribonucleic acid sequences.
BMC bioinformatics
Apr 20, 2024
BACKGROUND: MicroRNAs play a critical role in regulating gene expression by binding to specific target sites within gene transcripts, making the identification of microRNA targets a prominent focus of research. Conventional experimental methods for i...
Machine learning-driven prediction of brain metastasis in lung adenocarcinoma using miRNA profile and target gene pathway analysis of an mRNA dataset.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Apr 3, 2024
BACKGROUND: Brain metastasis (BM) is common in lung adenocarcinoma (LUAD) and has a poor prognosis, necessitating predictive biomarkers. MicroRNAs (MiRNAs) promote cancer cell growth, infiltration, and metastasis. However, the relationship between th...
Deepm6A-MT: A deep learning-based method for identifying RNA N6-methyladenosine sites in multiple tissues.
Methods (San Diego, Calif.)
Mar 12, 2024
N6-methyladenosine (m6A) is the most prevalent, abundant, and conserved internal modification in the eukaryotic messenger RNA (mRNAs) and plays a crucial role in the cellular process. Although more than ten methods were developed for m6A detection ov...
Comparing robotic and manual injection methods in zebrafish embryos for high-throughput RNA silencing using CRISPR-RfxCas13d.
BioTechniques
Feb 29, 2024
In this study, the authors compared the efficiency of automated robotic and manual injection methods for the CRISPR-RfxCas13d (CasRx) system for mRNA knockdown and Cas9-mediated DNA targeting in zebrafish embryos. They targeted the no tail () gene as...
Integrated multiplexed assays of variant effect reveal determinants of catechol-O-methyltransferase gene expression.
Molecular systems biology
Feb 14, 2024
Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expression in...
miTDS: Uncovering miRNA-mRNA interactions with deep learning for functional target prediction.
Methods (San Diego, Calif.)
Jan 26, 2024
MicroRNAs (miRNAs) are vital in regulating gene expression through binding to specific target sites on messenger RNAs (mRNAs), a process closely tied to cancer pathogenesis. Identifying miRNA functional targets is essential but challenging, due to in...
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