AIMC Topic: Sensitivity and Specificity

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An LC-MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies.

Journal of pharmaceutical and biomedical analysis
An LC-MS/MS method was developed for the determination of digitoxigenin in mice skin samples. Chromatographic separation was achieved on an Agilent Poroshell 120 EC-C18 column. Mass spectrometric detection was achieved by a triple-quadrupole mass spe...

Glycosaminoglycan levels in dried blood spots of patients with mucopolysaccharidoses and mucolipidoses.

Molecular genetics and metabolism
UNLABELLED: Mucopolysaccharidoses (MPSs) and mucolipidoses (ML) are groups of lysosomal storage disorders in which lysosomal hydrolases are deficient leading to accumulation of undegraded glycosaminoglycans (GAGs), throughout the body, subsequently r...

Characterizing Architectural Distortion in Mammograms by Linear Saliency.

Journal of medical systems
Architectural distortion (AD) is a common cause of false-negatives in mammograms. This lesion usually consists of a central retraction of the connective tissue and a spiculated pattern radiating from it. This pattern is difficult to detect due the co...

Classification of Exacerbation Frequency in the COPDGene Cohort Using Deep Learning With Deep Belief Networks.

IEEE journal of biomedical and health informatics
This study aims to develop an automatic classifier based on deep learning for exacerbation frequency in patients with chronic obstructive pulmonary disease (COPD). A three-layer deep belief network (DBN) with two hidden layers and one visible layer w...

The development of loop-mediated isothermal amplification combined with lateral flow dipstick for detection of Karlodinium veneficum.

Harmful algae
The aim of this study was to develop a loop-mediated isothermal amplification (LAMP) combined with a chromatographic lateral flow dipstick (LFD) assay to rapidly and specifically detect the Karlodinium veneficum ITS gene. Four groups of LAMP primers ...

Tomographic image reconstruction via estimation of sparse unidirectional gradients.

Computers in biology and medicine
Since computed tomography (CT) was developed over 35 years ago, new mathematical ideas and computational algorithms have been continuingly elaborated to improve the quality of reconstructed images. In recent years, a considerable effort can be notice...

Development of a Machine Learning Algorithm for the Surveillance of Autism Spectrum Disorder.

PloS one
The Autism and Developmental Disabilities Monitoring (ADDM) Network conducts population-based surveillance of autism spectrum disorder (ASD) among 8-year old children in multiple US sites. To classify ASD, trained clinicians review developmental eval...

ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.

The Kaohsiung journal of medical sciences
A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function. The aim of this ...