AIMC Topic: Signal Transduction

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Confirming an integrated pathology of diabetes and its complications by molecular biomarker-target network analysis.

Molecular medicine reports Jul 7, 2016
Despite ongoing research into diabetes and its complications, the underlying molecular associations remain to be elucidated. The systematic identification of molecular interactions in associated diseases may be approached using a network analysis str...
Signal Transduction Humans Diabetes Mellitus Neural Networks, Computer Metabolic Networks and Pathways Biomarkers Models, Biological Gene Regulatory Networks Diabetes Complications
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Classification of Motor Imagery EEG Signals with Support Vector Machines and Particle Swarm Optimization.

Computational and mathematical methods in medicine May 30, 2016
Support vector machines are powerful tools used to solve the small sample and nonlinear classification problems, but their ultimate classification performance depends heavily upon the selection of appropriate kernel and penalty parameters. In this st...
Models, Statistical Principal Component Analysis Electroencephalography Signal Processing, Computer-Assisted Hand Healthy Volunteers Foot Motor Skills Movement Imagination Computer Simulation Reproducibility of Results Adult Signal Transduction Support Vector Machine Humans Algorithms
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Drug target identification using network analysis: Taking active components in Sini decoction as an example.

Scientific reports Apr 20, 2016
Identifying the molecular targets for the beneficial effects of active small-molecule compounds simultaneously is an important and currently unmet challenge. In this study, we firstly proposed network analysis by integrating data from network pharmac...
Metabolomics Proteins Structure-Activity Relationship Metabolic Networks and Pathways Humans Drugs, Chinese Herbal Neural Networks, Computer Tumor Necrosis Factor-alpha Reproducibility of Results Cell Line, Tumor Signal Transduction Myocytes, Cardiac
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Naphthols Purinones Saphenous Vein Muscle, Smooth, Vascular Thiazolidines Hydrazones Thiourea Cell Movement Humans HEK293 Cells Dose-Response Relationship, Drug Time Factors Myocytes, Smooth Muscle Receptors, G-Protein-Coupled Cell Proliferation Endothelial Cells rho-Associated Kinases Signal Transduction Actin Cytoskeleton rhoA GTP-Binding Protein Aminosalicylic Acids
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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Humans Neural Networks, Computer Phenotype Computer Simulation Animals Signal Transduction Databases, Genetic Bayes Theorem Coronary Artery Disease Gene Regulatory Networks STAT3 Transcription Factor Mice Genetic Loci Genomics Gene Expression Profiling Gene Expression Regulation Genetic Predisposition to Disease Lumican Computational Biology Case-Control Studies Genome-Wide Association Study Protein Interaction Maps
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Network stratification analysis for identifying function-specific network layers.

Molecular bioSystems Feb 16, 2016
A major challenge of systems biology is to capture the rewiring of biological functions (e.g. signaling pathways) in a molecular network. To address this problem, we proposed a novel computational framework, namely network stratification analysis (Ne...
Carcinoma, Hepatocellular Protein Interaction Maps Gene Regulatory Networks Computational Biology Gene Expression Regulation, Neoplastic Algorithms Disease Progression Gene Expression Profiling Liver Neoplasms Signal Transduction Cluster Analysis Models, Biological Gene Expression Regulation, Fungal Transcription, Genetic Humans Neural Networks, Computer
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Detection of overlapping protein complexes in gene expression, phenotype and pathways of Saccharomyces cerevisiae using Prorank based Fuzzy algorithm.

Gene Jan 22, 2016
Proteins show their functional activity by interacting with other proteins and forms protein complexes since it is playing an important role in cellular organization and function. To understand the higher order protein organization, overlapping is an...
Cluster Analysis Databases, Protein Fungal Proteins Saccharomyces cerevisiae Gene Expression Regulation, Fungal Protein Interaction Mapping Multiprotein Complexes Algorithms Phenotype Computational Biology Signal Transduction Fuzzy Logic
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Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model.

BMC bioinformatics Jan 11, 2016
BACKGROUND: A living cell has a complex, hierarchically organized signaling system that encodes and assimilates diverse environmental and intracellular signals, and it further transmits signals that control cellular responses, including a tightly con...
Saccharomyces cerevisiae Proteins Signal Transduction Models, Theoretical Transcription Factors Saccharomyces cerevisiae Neural Networks, Computer Gene Expression Regulation, Fungal Computer Simulation Gene Expression Profiling Systems Biology
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Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory.

BMC bioinformatics Jan 11, 2016
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of death globally, and research into NSCLC has been accumulating steadily over several years. Drug repositioning is the current trend in the pharmaceutical industry for ident...
Carcinoma, Non-Small-Cell Lung Neoplasm Proteins Drug Repositioning Microarray Analysis Humans Machine Learning Algorithms Drug Discovery Antineoplastic Agents Lung Neoplasms Gene Expression Regulation, Neoplastic Signal Transduction Models, Theoretical
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Tumor Necrosis Factor-alpha Antioxidants Inflammation Signal Transduction Angiogenesis Inhibitors NF-E2-Related Factor 2 Humans Angiogenesis Inducing Agents Neovascularization, Pathologic Heme Oxygenase-1 Glutathione Basidiomycota Endothelial Cells Reactive Oxygen Species NF-kappa B Anti-Inflammatory Agents Matrix Metalloproteinase 9 Intercellular Adhesion Molecule-1
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