AIMC Topic: Spheroids, Cellular

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Automated spheroid generation, drug application and efficacy screening using a deep learning classification: a feasibility study.

Scientific reports Jul 6, 2020
The last two decades saw the establishment of three-dimensional (3D) cell cultures as an acknowledged tool to investigate cell behaviour in a tissue-like environment. Cells growing in spheroids differentiate and develop different characteristics in c...
Humans Neural Networks, Computer Neoplasms Deep Learning Tumor Cells, Cultured Spheroids, Cellular Cell Survival Drug Screening Assays, Antitumor Pharmaceutical Preparations Feasibility Studies
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Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

EMBO molecular medicine Jun 24, 2020
Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-c...
Betacoronavirus Pneumonia, Viral Azetidines Protein Kinase Inhibitors Purines Spheroids, Cellular Intracellular Signaling Peptides and Proteins Drug Evaluation, Preclinical Coronavirus Infections COVID-19 Drug Treatment Humans Pyrazoles Male Female Protein Serine-Threonine Kinases Artificial Intelligence Middle Aged SARS-CoV-2 Drug Repositioning Pandemics Antiviral Agents Leukocytes COVID-19 Aged Liver Cytokines Adult Sulfonamides
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How to Apply Supervised Machine Learning Tools to MS Imaging Files: Case Study with Cancer Spheroids Undergoing Treatment with the Monoclonal Antibody Cetuximab.

Journal of the American Society for Mass Spectrometry Jun 10, 2020
As the field of mass spectrometry imaging continues to grow, so too do its needs for optimal methods of data analysis. One general need in image analysis is the ability to classify the underlying regions within an image, as healthy or diseased, for e...
Supervised Machine Learning Tumor Cells, Cultured Spheroids, Cellular Cetuximab Humans Neoplasms Image Processing, Computer-Assisted Mass Spectrometry Metabolome
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Automating a Magnetic 3D Spheroid Model Technology for High-Throughput Screening.

SLAS technology Jun 21, 2019
Affordable and physiologically relevant three-dimensional (3D) cell-based assays used in high-throughput screening (HTS) are on the rise in early drug discovery. These technologies have been aided by the recent adaptation of novel microplate treatmen...
Automation, Laboratory Robotics Drug Evaluation, Preclinical High-Throughput Screening Assays Magnetics Cell Culture Techniques Spheroids, Cellular
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Anticancer Drug Affects Metabolomic Profiles in Multicellular Spheroids: Studies Using Mass Spectrometry Imaging Combined with Machine Learning.

Analytical chemistry Apr 15, 2019
Multicellular spheroids (hereinafter referred to as spheroids) are 3D biological models. The metabolomic profiles inside spheroids provide crucial information reflecting the molecular phenotypes and microenvironment of cells. To study the influence o...
HCT116 Cells Spheroids, Cellular Topoisomerase I Inhibitors Irinotecan Machine Learning Colorectal Neoplasms Metabolome Humans Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.

Journal of materials science. Materials in medicine Dec 30, 2017
In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell-cell and cell-matrix interactions that are essential for β-cell retention, viability and functional...
Trans-Activators Cadherins Betaine Molecular Dynamics Simulation Microscopy, Electron, Scanning Carbon Animals Homeodomain Proteins Surface Properties Insulin Secretion Cell Survival Insulin Scattering, Radiation Chitosan Insulin-Secreting Cells Lasers Spheroids, Cellular Mice Microscopy, Fluorescence Cell Culture Techniques Spectroscopy, Fourier Transform Infrared
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Hybrid-Actuating Macrophage-Based Microrobots for Active Cancer Therapy.

Scientific reports Jun 27, 2016
Using macrophage recruitment in tumors, we develop active, transportable, cancer theragnostic macrophage-based microrobots as vector to deliver therapeutic agents to tumor regions. The macrophage-based microrobots contain docetaxel (DTX)-loaded poly-...
Macrophages Animals Cell Line, Tumor Mice Spheroids, Cellular Robotics Cell- and Tissue-Based Therapy Magnetite Nanoparticles Theranostic Nanomedicine Neoplasms, Experimental
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Intelligent System for Automated Spheroid Segmentation Using Machine Learning.

Studies in health technology and informatics May 15, 2025
Image segmentation is a crucial task of medical image processing, including the analysis of multicellular tumour spheroids (MTSs), a common in vitro model used in cancer research for drug screening. Accurate segmentation of MTSs images allows the ext...
Microscopy Humans Pattern Recognition, Automated Artificial Intelligence Spheroids, Cellular Machine Learning Intelligent Systems Image Processing, Computer-Assisted
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Endoscopy-assisted magnetic navigation of biohybrid soft microrobots with rapid endoluminal delivery and imaging.

Science robotics Mar 17, 2021
High-precision delivery of microrobots at the whole-body scale is of considerable importance for efforts toward targeted therapeutic intervention. However, vision-based control of microrobots, to deep and narrow spaces inside the body, remains a chal...
Magnetics Sus scrofa Spheroids, Cellular Natural Orifice Endoscopic Surgery Equipment Design Male Microtechnology Female Computer Systems 3T3 Cells Endoscopy Ultrasonography Microscopy, Electron, Scanning Drug Delivery Systems Mice Rats Animals Rats, Sprague-Dawley Robotics Diagnostic Imaging Humans
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Deep-LUMEN assay - human lung epithelial spheroid classification from brightfield images using deep learning.

Lab on a chip Dec 15, 2020
Three-dimensional (3D) tissue models such as epithelial spheroids or organoids have become popular for pre-clinical drug studies. In contrast to 2D monolayer culture, the characterization of 3D tissue models from non-invasive brightfield images is a ...
Humans Lung Deep Learning Spheroids, Cellular Organoids
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