AIMC Topic: T-Lymphocytes
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Identification of prognostic genes related to T cell proliferation in papillary thyroid cancer based on single-cell RNA sequencing and bulk RNA sequencing data.
Clinical and experimental medicine
Aug 2, 2025
Papillary thyroid carcinoma (PTC) is the main pathological subtype of thyroid cancer. Given the strong association between T cells and PTC, this study focused on the prognostic value and potential molecular mechanisms of T cell proliferation-related ...
Beyond the native repertoire.
Science (New York, N.Y.)
Jul 24, 2025
Design of T cell receptors by artificial intelligence is poised to accelerate cancer immunotherapy.
Learning the sequence code of protein expression in human immune cells.
Science advances
Jul 23, 2025
Accurate protein expression in human immune cells is essential for appropriate cellular function. The mechanisms that define protein abundance are complex and are executed on transcriptional, posttranscriptional, and posttranslational levels. Here, w...
Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genes.
European journal of medical research
Jun 16, 2025
OBJECTIVES: The early diagnosis and immunoregulatory mechanisms of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remain unclear, and the role of metabolic genes in host-pathogen interactions requires further investigation.
Cross-organ hierarchy of HLA molecular mismatches in donor-specific antibody development in solid organ transplantations.
Cell reports. Medicine
May 30, 2025
Donor-specific antibodies (DSAs) against human leukocyte antigen (HLA) play a crucial role in antibody-mediated rejection, a major barrier to successful organ transplantation. Donor-recipient HLA molecular incompatibility critically influences DSA su...
Bioinformatics prediction of function of T-cell exhaustion related genes in ischemic stroke.
Scientific reports
May 29, 2025
Ischemic stroke (IS) is a multifactorial disease caused by the interaction of a variety of environmental and genetic factors, which can lead to severe disability and heavy social burden. This study aimed to find potential biomarkers related to T cell...
Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.
Frontiers in endocrinology
May 27, 2025
BACKGROUND: The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhausti...
Immunopeptidomics-guided discovery and characterization of neoantigens for personalized cancer immunotherapy.
Science advances
May 21, 2025
Neoantigens have emerged as ideal targets for personalized cancer immunotherapy. We depict the pan-cancer peptide atlas by comprehensively collecting immunopeptidomics from 531 samples across 14 cancer and 29 normal tissues, and identify 389,165 cano...
Celluloepidemiology-A paradigm for quantifying infectious disease dynamics on a population level.
Science advances
May 16, 2025
To complement serology as a tool in public health interventions, we introduced the "celluloepidemiology" paradigm where we leveraged pathogen-specific T cell responses at a population level to advance our epidemiological understanding of infectious d...
Machine learning approach to single cell transcriptomic analysis of Sjogren's disease reveals altered activation states of B and T lymphocytes.
Journal of autoimmunity
May 2, 2025
Sjogren's Disease (SjD) is an autoimmune disorder characterized by salivary and lacrimal gland dysfunction and immune cell infiltration leading to gland inflammation and destruction. Although SjD is a common disease, its pathogenesis is not fully und...
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