By transplanting pancreatic islets onto the dura mater of the mouse brain, we establish a microscopy platform that enables longitudinal intravital imaging of otherwise optically inaccessible tissue. The system combines a cranial window with an air-cu...
Sleep-wake states bidirectionally interact with epilepsy and seizures, but the mechanisms are unknown. A barrier to comprehensive characterization and the study of mechanisms has been the difficulty of annotating large chronic recording datasets. To ...
Time flows in one direction, a physical constraint humans recognize, as reflected in proverbs such as "there is no crying over spilt milk." Recent work from our laboratory has demonstrated that human participants rely on specific cues to discriminate...
The Journal of neuroscience : the official journal of the Society for Neuroscience
Aug 6, 2025
Identification of the neuron type is critical when using extracellular recordings in awake, behaving animal subjects to understand computation in neural circuits. Yet, modern recording probes have limited power to resolve neuron identity. Here, we pr...
Hypoglycemia is a major challenge for people with diabetes. Therefore, glycemic monitoring is an important aspect of diabetes management. However, current methods such as finger pricking and continuous glucose monitoring systems (CGMS) are invasive, ...
Accurately capturing the temporal distribution of polysomnographic sleep stages is critical for the study of sleep function, regulation, and disorders in higher vertebrates. In laboratory rodents, scoring of electrocorticography (ECoG) and electromyo...
Anesthesia plays a pivotal role in modern surgery by facilitating controlled states of unconsciousness. Precise control is crucial for safe and pain-free surgeries. Monitoring anesthesia depth accurately is essential to guide anesthesiologists, optim...
Exploring natural or pharmacologically induced brain dynamics, such as sleep, wakefulness, or anesthesia, provides rich functional models for studying brain states. These models allow detailed examination of unique spatiotemporal neural activity patt...
International journal of computer assisted radiology and surgery
Dec 9, 2024
PURPOSE: Awake craniotomy presents a unique opportunity to map and preserve critical brain functions, particularly speech, during tumor resection. The ability to accurately assess linguistic functions in real-time not only enhances surgical precision...
BACKGROUND: Positive neurologic awake testing during the carotid cross-clamping may be present in around 8% of patients undergoing carotid endarterectomy (CEA). The present work aimed to assess the accuracy of an artificial intelligence (AI)-powered ...
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