AIMC Topic: Aged

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Big Data Challenges Targeting Proteins in GPCR Signaling Pathways; Combining PTML-ChEMBL Models and [S]GTPγS Binding Assays.

ACS chemical neuroscience
G-protein-coupled receptors (GPCRs), also known as 7-transmembrane receptors, are the single largest class of drug targets. Consequently, a large amount of preclinical assays having GPCRs as molecular targets has been released to public sources like ...

Statistical and machine learning methodology for abdominal aortic aneurysm prediction from ultrasound screenings.

Echocardiography (Mount Kisco, N.Y.)
A method of analysis of a database of patients (n = 10 329) screened for an abdominal aortic aneurysm (AAA) is presented. Self-reported height, weight, age, gender, ethnicity, and parameters "Heart Problems," "Hypertension," "High Cholesterol," "Diab...

Predicting the Swallow-Related Quality of Life of the Elderly Living in a Local Community Using Support Vector Machine.

International journal of environmental research and public health
This study developed a support vector machine (SVM) algorithm-based prediction model with considering influence factors associated with the swallowing quality-of-life as the predictor variables and provided baseline information for enhancing the swa...

Machine Learning Models for Analysis of Vital Signs Dynamics: A Case for Sepsis Onset Prediction.

Journal of healthcare engineering
OBJECTIVE: Achieving accurate prediction of sepsis detection moment based on bedside monitor data in the intensive care unit (ICU). A good clinical outcome is more probable when onset is suspected and treated on time, thus early insight of sepsis ons...

Intravascular ultrasound-based machine learning for predicting fractional flow reserve in intermediate coronary artery lesions.

Atherosclerosis
BACKGROUND AND AIMS: Intravascular ultrasound (IVUS)-derived morphological criteria are poor predictors of the functional significance of intermediate coronary stenosis. IVUS-based supervised machine learning (ML) algorithms were developed to identif...

Machine-learned analysis of side-differences in odor identification performance.

Neuroscience
A right-left dichotomy of olfactory processes has been recognized on several levels of the perception or processing of olfactory input. On a clinical level, the lateralization of components of human olfaction is contrasted by the predominantly birhin...

A distributed multitask multimodal approach for the prediction of Alzheimer's disease in a longitudinal study.

NeuroImage
Predicting the progression of Alzheimer's Disease (AD) has been held back for decades due to the lack of sufficient longitudinal data required for the development of novel machine learning algorithms. This study proposes a novel machine learning algo...

Machine-learning-derived rules set excludes risk of Parkinson's disease in patients with olfactory or gustatory symptoms with high accuracy.

Journal of neurology
BACKGROUND: Chemosensory loss is a symptom of Parkinson's disease starting already at preclinical stages. Their appearance without an identifiable etiology therefore indicates a possible early symptom of Parkinson's disease. Supervised machine-learni...

A Gradient Boosting Machine Learning Model for Predicting Early Mortality in the Emergency Department Triage: Devising a Nine-Point Triage Score.

Journal of general internal medicine
BACKGROUND: Emergency departments (ED) are becoming increasingly overwhelmed, increasing poor outcomes. Triage scores aim to optimize the waiting time and prioritize the resource usage. Artificial intelligence (AI) algorithms offer advantages for cre...