AIMC Topic: Animals

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Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion.

Basic research in cardiology
Infarct size (IS) is the most robust end point for evaluating the success of preclinical studies on cardioprotection. The gold standard for IS quantification in ischemia/reperfusion (I/R) experiments is triphenyl tetrazolium chloride (TTC) staining, ...

Artificial intelligence-based digital pathology for the detection and quantification of soil-transmitted helminths eggs.

PLoS neglected tropical diseases
BACKGROUND: Conventional microscopy of Kato-Katz (KK1.0) thick smears, the primary method for diagnosing soil-transmitted helminth (STH) infections, has limited sensitivity and is error-prone. Artificial intelligence-based digital pathology (AI-DP) m...

Integrating machine learning to advance epitope mapping.

Frontiers in immunology
Identifying epitopes, or the segments of a protein that bind to antibodies, is critical for the development of a variety of immunotherapeutics and diagnostics. In vaccine design, the intent is to identify the minimal epitope of an antigen that can el...

Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.

Journal of advanced research
INTRODUCTION: Triple-negative breast cancer (TNBC) is the primary cause of breast cancer-induced death in women. Literature has confirmed the benefits of Salidroside (Sal) in treating TNBC. However, the study about potential therapeutic targets and m...

Learning to segment self-generated from externally caused optic flow through sensorimotor mismatch circuits.

Neural networks : the official journal of the International Neural Network Society
Efficient sensory detection requires the capacity to ignore task-irrelevant information, for example when optic flow patterns created by egomotion need to be disentangled from object perception. To investigate how this is achieved in the visual syste...

Comparison of a machine learning model with a conventional rule-based selective dry cow therapy algorithm for detection of intramammary infections.

Journal of dairy science
We trained machine learning models to identify IMI in late-lactation cows at dry-off to guide antibiotic treatment, and compared their performance to a rule-based algorithm that is currently used on dairy farms in the United States. We conducted an o...

Machine-learning based prediction model for acute kidney injury induced by multiple wasp stings.

Toxicon : official journal of the International Society on Toxinology
Acute kidney injury (AKI) following multiple wasp stings is a severe complication with potentially poor outcomes. Despite extensive research on AKI's risk factors, predictive models for wasp sting-related AKI are limited. This study aims to develop a...

Graphene Microelectrode Arrays, 4D Structured Illumination Microscopy, and a Machine Learning Spike Sorting Algorithm Permit the Analysis of Ultrastructural Neuronal Changes During Neuronal Signaling in a Model of Niemann-Pick Disease Type C.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Simultaneously recording network activity and ultrastructural changes of the synapse is essential for advancing understanding of the basis of neuronal functions. However, the rapid millisecond-scale fluctuations in neuronal activity and the subtle su...

Capture of RNA-binding proteins across mouse tissues using HARD-AP.

Nature communications
RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism, but a comprehensive picture of RBP expression across tissues is lacking. Here, we describe our development of the method we call HARD-AP that robustly retrieves RBPs and tightly asso...

Improving lameness detection in cows: A machine learning algorithm application.

Journal of dairy science
The deployment of diverse data-generating technologies in livestock farming holds the promise of early disease detection and improved animal well-being. In this paper, we combine routinely collected dairy farm and herd data with weather and high-freq...