The Journal of neuroscience : the official journal of the Society for Neuroscience
Jan 7, 2026
Drawing on philosophical theories of knowledge, I develop a conceptual framework for knowledge in animals and machines. I use this framework to engineer a new concept of large language model (LLM) knowledge and propose a taxonomy of knowledge that sp...
The neocortex is composed of spiking neurons interconnected in a sparse, recurrent network. Spiking activity within these networks underlies the computations that transform sensory inputs into appropriate behavioral responses. In this study, we train...
Inflammatory bowel disease (IBD) is a heterogeneous group of disorders characterized primarily by chronic relapsing intestinal inflammation, encompassing Crohn's disease (CD) and ulcerative colitis (UC), affecting individuals across age groups with v...
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jan 7, 2026
Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments (e.g., all-optical interrogation, closed-loop control) for interrogating neural circuits. Unfortunately, these a...
Butyrylcholinesterase (BChE) may serve as a scavenger enzyme protecting against various toxic compounds, but we still don't fully understand how it interacts with fentanyl analogues. We investigated how Despropionyl -methyl fentanyl (DPPM) inhibits e...
, the fruit fly, uses the neurotransmitters dopamine and octopamine to mediate learning, enabling adaptive behaviors such as reward seeking and punishment avoidance. Their colocalization in the mushroom bodies makes it challenging to study their indi...
The reach and scope of minimally invasive surgical procedures can be transformed via the development of continuum robots. Through soft, flexible structures and accurate navigation, previously inaccessible anatomical regions can be safely reached. Dep...
Journal of chemical information and modeling
Dec 31, 2025
The accurate and efficient computational identification of interferon-gamma-inducing epitopes (IFNgIE) is a critical bottleneck in the design of next-generation vaccines and immunotherapies. Existing computational models, while adept at learning sequ...
Soft-body grippers are highly pliable due to the use of flexible materials, which enable safe grasping of objects, but their load-bearing capacity is limited by the mechanical properties of the materials themselves. To address the problem of insuffic...
Blood-based testing represents a valuable tool for the detection and monitoring of patient conditions in both human and veterinary medicine. When conventional tissue-based diagnosis is challenging, blood-derived measurements allow for minimally invas...
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