International journal of pharmaceutics
Aug 24, 2025
PURPOSE: The development of a novel lipid-based formulation for apalutamide, a potent androgen receptor inhibitor for non-metastatic castration-resistant prostate cancer (nmCRPC), is explored in this study.
International journal of molecular medicine
Aug 24, 2025
Pathogens, including bacteria, viruses and fungi, employ virulence genes to invade their hosts, circumvent immunity and induce diseases. The present review examines the categorization and regulatory mechanisms of virulence genes and their co‑evolutio...
Managing inflammation in diabetic chronic wounds remains a major clinical challenge, primarily due to the lack of real-time monitoring techniques. To address this issue, we developed a peptide hydrogel capable of simultaneously monitoring the inflamm...
The first embryonic division of Caenorhabditis elegans is a model for asymmetric cell division, and identifying the stages of cell division across related species could improve our understanding of the divergence of cellular events and mechanisms. Co...
Cholangiocarcinoma (CCA) is a prevalent malignancy in countries along Mekong basin, closely linked to chronic infections caused by Opisthorchis viverrini (OV). Early detection of OV-infected individuals holds significant promise for screening at-risk...
Awareness of the intestinal microflora involved in insulin resistance and type 2 diabetes (T2DM) has now become more evident. However, direct mechanical insight is required to illustrate the contribution of intestinal microflora in the disease progre...
Biosimilar artificial mucus models that mimic native mucus facilitate efficient, lab-based drug diffusion studies, addressing the costly and challenging preclinical phase of drug development, especially for nano- and micro-scale particle-based coloni...
Influenza A viruses (IAVs) have historically posed significant public health threats, causing severe pandemics. Viral host specificity is typically constrained by host barriers, limiting the range of species that can be infected. However, these barri...
Immense progress in synthetic micro-/nanorobots with diverse functionalities has been made for biomedical applications during the last decade. However, there is still a huge gap for miniature robots to realize efficient therapy from in vitro to in vi...
Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of acti...
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