AIMC Topic: Animals
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Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling.
Drug design, development and therapy
Apr 21, 2025
PURPOSE: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.
SagMSI: A graph convolutional network framework for precise spatial segmentation in mass spectrometry imaging.
Analytica chimica acta
Apr 19, 2025
BACKGROUND: Mass Spectrometry Imaging (MSI) is a label-free imaging technique used in spatial metabolomics to explore the distribution of various metabolites within biological tissues. Spatial segmentation plays a crucial role in the biochemical inte...
Coptidis rhizoma and berberine as anti-cancer drugs: A 10-year updates and future perspectives.
Pharmacological research
Apr 19, 2025
Cancer continues to be among the most substantial health challenges globally. Among various natural compounds, berberine, an isoquinoline alkaloid obtained from Coptidis Rhizoma, has garnered considerable attention for its broad-spectrum biological a...
Construction of a deep learning model and identification of the pivotal characteristics of FGF7- and MGST1- positive fibroblasts in heart failure post-myocardial infarction.
International journal of biological macromolecules
Apr 19, 2025
Dysregulation of fibroblast function is closely associated with the occurrence of heart failure after myocardial infarction (post-MI HF). Myocardial fibrosis is a detrimental consequence of aberrant fibroblast activation and extracellular matrix depo...
Rapid and chemical-free technique based on hyperspectral imaging combined with artificial intelligence for monitoring quality and shelf life of dried shrimp.
Food research international (Ottawa, Ont.)
Apr 18, 2025
A rapid and chemical-free method based on hyperspectral imaging (HSI) integrated with artificial intelligence (AI) for monitoring dried shrimp quality was developed. Dried shrimp was packaged in a polypropylene bag and chronologically monitored for c...
ULK2 deficiency stratifies autophagy-driven molecular subtypes and exacerbates trophoblasts apoptosis in preeclampsia.
Placenta
Apr 18, 2025
INTRODUCTION: Preeclampsia (PE), a placenta-originated hypertensive disorder of pregnancy, lacks targeted therapies despite its significant contribution to maternal and fetal morbidity. Emerging evidence implicates autophagy dysregulation in PE patho...
Comprehensive evaluation and application of tissue clearing techniques for 3-D visualization of splenic neural and immune architecture.
American journal of physiology. Cell physiology
Apr 18, 2025
As the largest secondary lymphoid organ, the spleen plays a crucial role in initiating and sustaining immune responses against blood-borne pathogens through antigen capture and delivery. It is innervated by both autonomic and sensory nerves, which al...
Comprehensive insights into carbonic anhydrase inhibition: A triad of In vitro, In silico, and In vivo perspectives.
Enzyme and microbial technology
Apr 17, 2025
Carbonic anhydrases (CAs) are zinc-dependent metalloenzymes essential for sustaining physiological balance by facilitating the reversible conversion of carbon dioxide to its hydrated form. Their biological significance, coupled with their involvement...
Non-destructive measurement of eggshell strength using NIR spectroscopy and explainable artificial intelligence.
Journal of the science of food and agriculture
Apr 17, 2025
BACKGROUND: Eggshell strength is crucial for ensuring high-quality eggs, reducing breakage during handling, and meeting consumer expectations for freshness and integrity. Conventional methods of eggshell strength measurement are often destructive, ti...
Model-driven high-throughput zebrafish embryo assay for evaluating whole effluent toxicity variation across 100 full-scale wastewater treatment plants.
Water research
Apr 17, 2025
The zebrafish embryo is a valuable model for evaluating whole effluent toxicity (WET). However, the widely recognized acute toxicity indicator, based on International Organization of Standardization (ISO) methods, requires large numbers of embryos an...
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