AIMC Topic: Animals
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A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the ventral nerve cord.
eLife
Jun 10, 2025
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due t...
Automated classification of seizure onset pattern using intracranial electroencephalogram signal of non-human primates.
Physiological measurement
Jun 10, 2025
To develop and validate a machine learning framework for the classification of distinct seizure onset patterns using intracranial EEG (iEEG) recordings in a non-human primate (NHP) model of penicillin-induced seizures.iEEG data were collected from si...
What does evolution make? Learning in living lineages and machines.
Trends in genetics : TIG
Jun 10, 2025
How does genomic information unfold, to give rise to self-constructing living organisms with problem-solving capacities at all levels of organization? We review recent progress that unifies work in developmental genetics and machine learning (ML) to ...
Dynamics and design of passive tails for enhanced stability of motion.
Bioinspiration & biomimetics
Jun 6, 2025
In this work, we study the nonlinear dynamics of tail motion using numerical simulations and experiments. Our simulations are based on a discrete model comprising rigid cylinders (representing vertebrae) coupled by longitudinal, shear, and bending sp...
Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex.
Nature neuroscience
Jun 6, 2025
From visual perception to language, sensory stimuli change their meaning depending on previous experience. Recurrent neural dynamics can interpret stimuli based on externally cued context, but it is unknown whether they can compute and employ interna...
Fusing multisensory signals across channels and time.
PLoS computational biology
Jun 6, 2025
Animals continuously combine information across sensory modalities and time, and use these combined signals to guide their behaviour. Picture a predator watching their prey sprint and screech through a field. To date, a range of multisensory algorith...
The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update.
Expert opinion on drug discovery
Jun 5, 2025
INTRODUCTION: The landscape of drug discovery is rapidly evolving, with natural products (NPs) playing a pivotal role in the development of novel therapeutics. Despite their historical significance, challenges persist in fully harnessing their potent...
Construction of a deep learning-based predictive model to evaluate the influence of mechanical stretching stimuli on MMP-2 gene expression levels in fibroblasts.
Biomedical engineering online
Jun 5, 2025
BACKGROUND: Matrix metalloproteinase-2 (MMP-2) secretion homeostasis, governed by the multifaceted interplay of skin stretching, is a pivotal determinant influencing wound healing dynamics. This investigation endeavors to devise an artificial intelli...
Encoding flexible gait strategies in stick insects through data-driven inverse reinforcement learning.
Bioinspiration & biomimetics
Jun 5, 2025
Stick insects exhibit remarkable adaptive walking capabilities across diverse environments; however, the mechanisms underlying their gait transitions remain poorly understood. Although reinforcement learning (RL) has been employed to generate insect-...
Underwater bionic undulating fins incorporating thickness effects: hydrodynamic performance and optimal thickness variation rate analysis.
Bioinspiration & biomimetics
Jun 5, 2025
In response to the urgent issues faced by current bionic undulating fin robot propulsion mechanisms, such as low working efficiency, insufficient swimming speed, ignoring thickness parameters, and the need for further improvement in biomimetic degree...
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