- Herbal Pair (SEHP) is one of the classic Chinese herbal formulas for treating Alzheimer's disease (AD), but its complex chemical composition renders traditional analytical methods inefficient. Retention time (RT) provides complementary information ...
Immune checkpoint inhibitors have partially improved treatment outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but the response rate remains low, with only a few patients benefiting. Mechanistically, HNSCC tumor cells often ...
Chemical neuroscience wields tools to uncover the molecular mysteries of the brain. Sensors can be fabricated with properties tailored to the scales needed to decode neurochemical information. Current instrumentation is capable of measurement rates t...
Myocardial ischemia-reperfusion injury (MIRI), a frequent complication in acute myocardial infarction (AMI) treatment, arises from complex mechanisms including oxidative stress, inflammation, and mitochondrial dysfunction, which impair myocardial rep...
Proceedings of the National Academy of Sciences of the United States of America
Dec 10, 2025
Social information processing involves coordinated neural activity across distributed brain circuits, with the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) playing pivotal roles. However, whether these regions employ distinct coding...
Classification constitutes a fundamental cognitive challenge for both biological and artificial intelligence systems. Here, we investigated how the brain categorizes stimuli that are not linearly separable in the physical world by analyzing the geome...
Bacterial-mediated drug delivery has emerged as a promising strategy for disease treatment, leveraging bacteria's innate ability to penetrate biological barriers and target diseased tissues. However, existing bacteria-nanoparticle hybrid systems ofte...
Messenger RNA (mRNA) vaccines face core challenges including low-delivery efficiency and immunogenicity, limiting their wide-ranging applications in infectious disease prevention and cancer therapy. Lipid nanoparticles (LNPs), the most clinically val...
International journal of pharmaceutics
Dec 9, 2025
Exosomes are small, membrane-enclosed vesicles that can originate from a variety of sources and contain a wealth of material. They are involved in physiological processes such as cell-cell communication, cell migration, and anti-tumor immunity, and a...
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