Current first-line treatments of paediatric ulcerative colitis (UC) maintain a 6-month remission in only half of the patients. Relapse prediction at diagnosis could enable earlier introduction of immunosuppressants. We collected intestinal biopsies f...
Spiking neural networks (SNNs) are biologically more plausible and computationally more powerful than artificial neural networks due to their intrinsic temporal dynamics. However, vanilla spiking neurons struggle to simultaneously encode spatiotempor...
Nonalcoholic fatty liver disease (NAFLD) is emerging as the leading cause of chronic liver disease in many regions, particularly in association with the rising prevalence of Metabolic syndrome (MetS), affecting more than 30% of the population worldwi...
Alzheimer's disease (AD) biomarkers (Aβ42 or Tau 181) have high diagnostic performance. However, when they are altered, it indicates that irreversible pathology has developed in the brain. Therefore, there is a lack of early prediction or monitoring ...
In this study, we investigate the efficacy of optical photothermal infrared (O-PTIR) spectroscopy, also known as mid-infrared photothermal (MIP) microscopy, for label-free and nondestructive detection of micro- and nanoplastics (MNPs) down to diamete...
As a typical pest affecting corn yield and safety, corn borer causes serious economic losses worldwide. Climate warming has intensified the occurrence of pest outbreaks in recent years, but the associated risk has not been precisely assessed or under...
Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...
Ferritin is an iron-storage protein that naturally self-assembles into a hollow spherical particle consisting of 24 identical subunits, and it serves a central role in iron metabolism. Ferritin's favorable drug-loading capacity, biocompatibility, int...
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, making effective treatments essential to improve patient survival. To advance the understanding of GBM and develop more effective therapies, preclinical studies commonly use m...
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