AIMC Topic: Animals

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Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis.

Nature communications
Current first-line treatments of paediatric ulcerative colitis (UC) maintain a 6-month remission in only half of the patients. Relapse prediction at diagnosis could enable earlier introduction of immunosuppressants. We collected intestinal biopsies f...

A multisynaptic spiking neuron for simultaneously encoding spatiotemporal dynamics.

Nature communications
Spiking neural networks (SNNs) are biologically more plausible and computationally more powerful than artificial neural networks due to their intrinsic temporal dynamics. However, vanilla spiking neurons struggle to simultaneously encode spatiotempor...

NAFLD progression in metabolic syndrome: a Raman spectroscopy and machine learning approach in an animal model.

The Analyst
Nonalcoholic fatty liver disease (NAFLD) is emerging as the leading cause of chronic liver disease in many regions, particularly in association with the rising prevalence of Metabolic syndrome (MetS), affecting more than 30% of the population worldwi...

Multi-omics analysis of plasma and CSF in spontaneous diabetic cynomolgus monkeys: Unravelling and validating the key molecular markers that predict the preclinical pathological formation of Alzheimer's disease.

Computers in biology and medicine
Alzheimer's disease (AD) biomarkers (Aβ42 or Tau 181) have high diagnostic performance. However, when they are altered, it indicates that irreversible pathology has developed in the brain. Therefore, there is a lack of early prediction or monitoring ...

Detection of Unlabeled Polystyrene Micro- and Nanoplastics in Mammalian Tissue by Optical Photothermal Infrared Spectroscopy.

Analytical chemistry
In this study, we investigate the efficacy of optical photothermal infrared (O-PTIR) spectroscopy, also known as mid-infrared photothermal (MIP) microscopy, for label-free and nondestructive detection of micro- and nanoplastics (MNPs) down to diamete...

Risk assessment of corn borer based on feature optimization and weighted spatial clustering: a case study in Shandong Province, China.

Scientific reports
As a typical pest affecting corn yield and safety, corn borer causes serious economic losses worldwide. Climate warming has intensified the occurrence of pest outbreaks in recent years, but the associated risk has not been precisely assessed or under...

Integrative network pharmacology and multi-omics reveal anisodamine hydrobromide's multi-target mechanisms in sepsis.

Scientific reports
Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...

Structural modification strategies for ferritin nanoparticles and their applications in biomedicine: a narrative review.

Nanoscale
Ferritin is an iron-storage protein that naturally self-assembles into a hollow spherical particle consisting of 24 identical subunits, and it serves a central role in iron metabolism. Ferritin's favorable drug-loading capacity, biocompatibility, int...

Advances in mass spectrometry of lipids for the investigation of Niemann-pick type C disease.

Lipids in health and disease
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...

High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor.

Scientific data
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, making effective treatments essential to improve patient survival. To advance the understanding of GBM and develop more effective therapies, preclinical studies commonly use m...